Q65HJ2

PR
Gene name
dxs
Protein name
1-deoxy-D-xylulose-5-phosphate synthase
Names
1-deoxyxylulose-5-phosphate synthase, DXP synthase, DXPS
Species
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)
KEGG Pathway
bli:BL01523
EC number
2.2.1.7: Transketolases and transaldolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

78-149 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q65HJ2

Entry ID Method Resolution Chain Position Source
AF-Q65HJ2-F1 Predicted AlphaFoldDB

No variants for Q65HJ2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q65HJ2

No associated diseases with Q65HJ2

4 regional properties for Q65HJ2

Type Name Position InterPro Accession
domain Transketolase, N-terminal 28 - 47 IPR005474
domain Transketolase-like, pyrimidine-binding domain 316 - 481 IPR005475
binding_site Transketolase binding site 422 - 438 IPR020826
domain Transketolase, C-terminal domain 493 - 615 IPR033248

Functions

Description
EC Number 2.2.1.7 Transketolases and transaldolases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

3 GO annotations of molecular function

Name Definition
1-deoxy-D-xylulose-5-phosphate synthase activity Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2).
magnesium ion binding Binding to a magnesium (Mg) ion.
thiamine pyrophosphate binding Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.

3 GO annotations of biological process

Name Definition
1-deoxy-D-xylulose 5-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of 1-deoxy-D-xylulose 5-phosphate, the 5-phospho derivative of 1-deoxy-D-xylulose. 1-deoxy-D-xylulose 5-phosphate is an intermediate in the non-mevalonate pathway and a common precursor for isoprenoid, thiamin, and pyridoxol biosynthesis.
terpenoid biosynthetic process The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDLLSIKDPA FLKNLSNEEL ESLSAEIRRF LIETLSESGG HIGPNLGVVE LTIALHKEFD
70 80 90 100 110 120
SPKDKFLWDV GHQSYVHKLL TGRGKDFATL RQHKGLCGFP KRNESEHDVW ETGHSSTSLS
130 140 150 160 170 180
GAMGMAAARD LKGTNEYIIP IIGDGALTGG MALEALNHIG HEQKDMIVIL NDNEMSIAPN
190 200 210 220 230 240
VGAIHSMLGR LRTAGKYQWV KDELEYLFKR IPAVGGKLAA TAERIKDSLK YLLVSGMFFE
250 260 270 280 290 300
ELGFTYLGPV DGHSYDELFE NLQYAKKTKG PVLLHVITKK GKGYKPAETD KTGTWHGTGP
310 320 330 340 350 360
YKIDTGDFVK PKAAAPSWSS LVSETVRKLA REDERIVAIT PAMPVGSKLE GFASEFPERM
370 380 390 400 410 420
FDVGIAEQHA ATMAAGLATQ NMKPFLAIYS TFLQRAYDQV VHDICRQNLN VFIGIDRAGL
430 440 450 460 470 480
VGADGETHQG VFDIAFLRHI PNLVLMMPKD ENEGQHMVNT AVKYDDGPIA MRFPRGNGLG
490 500 510 520 530 540
VKMDKELKTI PIGTWEVLRP GTDAVILTFG TTIPMALAAA EELQKEGRSV RVVNARFIKP
550 560 570 580 590 600
LDENMLKEIL NEGLPILTIE EAVLQGGFGS SILEFAHEHQ SYSPIIDRMG IPDQFIEHGS
610 620 630
VAKLLEEIGM TKEDVIRRIR LLTPVKTHKG IGS