Q65GS5

PR
Gene name
alaS
Protein name
Alanine--tRNA ligase
Names
Alanyl-tRNA synthetase, AlaRS
Species
Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)
KEGG Pathway
bli:BL02033
EC number
6.1.1.7: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

34-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q65GS5

Entry ID Method Resolution Chain Position Source
AF-Q65GS5-F1 Predicted AlphaFoldDB

No variants for Q65GS5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q65GS5

No associated diseases with Q65GS5

4 regional properties for Q65GS5

Type Name Position InterPro Accession
domain DHHA1 domain 735 - 874 IPR003156
domain Threonyl/alanyl tRNA synthetase, SAD 655 - 698 IPR012947
domain Alanyl-tRNA synthetase, class IIc, N-terminal 8 - 556 IPR018164
domain Alanyl-tRNA synthetase, class IIc, core domain 4 - 711 IPR018165

Functions

Description
EC Number 6.1.1.7 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
alanine-tRNA ligase activity Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala).
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
tRNA binding Binding to a transfer RNA.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
alanyl-tRNA aminoacylation The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTLTSAQVR QMFLDFFKEK GHAVEPSASL IPHEDPSLLW INSGVATLKK YFDGRVVPEN
70 80 90 100 110 120
PRICNAQKSI RTNDIENVGK TARHHTFFEM LGNFSIGDYF KEEAIEWAWE FLTDQKWIGF
130 140 150 160 170 180
DPERLSVTVH PEDDEAYELW SKKIGIPEER IIRLEGNFWD IGEGPSGPNT EIFYDRGEDY
190 200 210 220 230 240
GNDPSDPELY PGGENERYLE VWNLVFSEFN HNPDGTYTPL PKKNIDTGMG LERMVSVIQD
250 260 270 280 290 300
AKTNYDTDLF MPIIKATEAI SGEKYGTSAE KDTAFKVVAD HIRTAAFAVG DGALPSNEGR
310 320 330 340 350 360
GYVIRRLLRR AVRYAKSINI NRPFMYELVP VVADIMAAFY GEVKEKADFI AKVIKTEEER
370 380 390 400 410 420
FHETLHEGLA ILSEVIQKEK AKGNRIISGE DVFKLYDTYG FPVELTEEYA EDEGMEVDHE
430 440 450 460 470 480
GFEREMDKQR ERARQARQDV GSMQVQGGAL RDIMTESEFI GYSDIKTETK IAELLQDGEL
490 500 510 520 530 540
VDLVQEGQKV QFILEKTPFY AESGGQIGDK GWVKSGDAAI RVTDVKKAPN GQHLHEGIVE
550 560 570 580 590 600
SGAIKKGMSV TAEVTERLRK DIVKNHTATH LLHQALKDVL GTHVNQAGSL VTDSRLRFDF
610 620 630 640 650 660
SHFGQVTKEE LEQIETKVNE KIWASIPVQI DLKPIAEAKA MGAMALFGEK YGDIVRVVQV
670 680 690 700 710 720
GDYSIELCGG CHVRNTAEIG LFKIVSESGI GAGTRRIEAV TGQGAYEEMN AKLELLEQAA
730 740 750 760 770 780
EVLKTNVKEV PKRIEALQSD LKDAQRENES LLAKLGNKEA GEILEKVKEI DGIKLLAEKV
790 800 810 820 830 840
NAKDMNHLRT MVDDLKAKLG SAVIVLGAVQ NEKVNISAGV TKDLIERGFH AGKLVKQVAE
850 860 870
ACGGGGGGRP DMAQAGGKQP ERLAEALASA EEWVKSVL