Q65525

PR
Gene name
Protein name
Outer capsid protein VP4
Names
Hemagglutinin
Species
Rotavirus C (isolate RVC/Cow/Japan/Shintoku/1991/G2P[3]) (RV-C)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

21-90 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q65525

Entry ID Method Resolution Chain Position Source

No variants for Q65525

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q65525

No associated diseases with Q65525

3 regional properties for Q65525

Type Name Position InterPro Accession
domain Haemagglutinin outer capsid protein VP4, concanavalin-like domain 65 - 230 IPR000416
domain Rotavirus VP4 helical domain 486 - 733 IPR035329
domain Rotavirus VP4, membrane interaction domain 251 - 475 IPR035330

Functions

Description
EC Number
Subcellular Localization
  • [Outer capsid protein VP4]: Virion
  • Host rough endoplasmic reticulum
  • Host cell membrane
  • Host endoplasmic reticulum-Golgi intermediate compartment
  • The outer layer contains 180 copies of VP4, grouped as 60 dimers
  • Immature double-layered particles assembled in the cytoplasm bud across the membrane of the endoplasmic reticulum, acquiring during this process a transient lipid membrane that is modified with the ER resident viral glycoproteins NSP4 and VP7; these enveloped particles also contain VP4
  • As the particles move towards the interior of the ER cisternae, the transient lipid membrane and the non-structural protein NSP4 are lost, while the virus surface proteins VP4 and VP7 rearrange to form the outermost virus protein layer, yielding mature infectious triple-layered particles
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
host cell endoplasmic reticulum-Golgi intermediate compartment A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport.
host cell plasma membrane The plasma membrane surrounding a host cell.
host cell rough endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
viral outer capsid The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
permeabilization of host organelle membrane involved in viral entry into host cell Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm.
viral entry via permeabilization of inner membrane The entry of a non-enveloped virus into the cytoplasm of a host prokaryotic cell, following fusion with the outer membrane, via permeabilization of the plasma (inner) membrane. In the case of some double stranded RNA viruses of prokaryotes this occurs via interaction of a membrane-interacting component of the capsid, leading to depolarization an permeabilization of the plasma membrane.
virion attachment to host cell The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASSLYRQLI SQNYYSTGNE ILLDQQTNKT TVDYVDAGNY TYAQLPPTTW GAESTYESAF
70 80 90 100 110 120
SAPEITGPYT NTVIKLSDLS DSNVWVLYQK PTSTVKLLKN GPESYSWNLA AFELWYGKAN
130 140 150 160 170 180
TTVTSDYYSG MTNSEKSVEV DHDSLVLFWN EGSTALSNKV INFSWNVGGV LIKLTSNTRI
190 200 210 220 230 240
DICMANMDNF TSDSFNWEEW THNFPRSASM NIYTDYYLAS VDPYSQIRAL QQPIITTVEM
250 260 270 280 290 300
KMVKVKREGS INVDEVVSKD SLWQEVRYVR DITLQCKIES EVVKGGGWGY DYTSVAFKTI
310 320 330 340 350 360
NHTYSYTRAG EAVNAHVTIS FNNLKERSYG GSLPTDFKIG RFDIIDVDTY MYIDYWDDSE
370 380 390 400 410 420
IFKNMVYVRD LRADMGGFNY SSAMSYYFRI PVGQYPGLHS SGVRFTYERS LLSQQFTDQV
430 440 450 460 470 480
ALNSMRFVFR ATSSDGWFMT AGNINARRIA SGTGFAYSDG YVTETVGTVS FISLIPSNPN
490 500 510 520 530 540
YQTPIASSST VRMDLERKIN DLRNDFNELA SSVALGDILS LAMSPLTFAN LLESVPAIAS
550 560 570 580 590 600
SVKDVAANVM KKFKTTKMFK KAAKPKYKEY IIGDLLEDVT NLPRSTTAMD FDDITSAVMV
610 620 630 640 650 660
STTNRLQLTD VETLSEIVAR SADDFIPNRA YRMIEDGMVH EATPNGVFSY DLATLQQRNF
670 680 690 700 710 720
DMEKFMQLAS KSPVISAIVD FATLKAMRDT YGVSTDIMYK LVASDAPTIV SFINNNNPLI
730
RNRIEGLLRQ CRI