Q64962

PR
Gene name
ORF1
Protein name
RNA replication polyprotein
Names
ORF1 protein
Species
Apple stem pitting virus (isolate PA66) (ASPV)
KEGG Pathway
vg:935270
EC number
2.7.7.48: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

849-939 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for Q64962

Entry ID Method Resolution Chain Position Source

No variants for Q64962

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q64962

No associated diseases with Q64962

7 regional properties for Q64962

Type Name Position InterPro Accession
domain RNA-dependent RNA polymerase, alsuviricetes 1764 - 2169 IPR001788
domain Alphavirus-like methyltransferase (MT) domain 43 - 353 IPR002588
domain OTU domain 1091 - 1199 IPR003323
domain Oxoglutarate/iron-dependent dioxygenase 762 - 853 IPR005123
domain RNA-directed RNA polymerase, catalytic domain 1961 - 2068 IPR007094
domain Peptidase C23 1198 - 1288 IPR008041
domain (+) RNA virus helicase core domain 1349 - 1667 IPR027351

Functions

Description
EC Number 2.7.7.48 Nucleotidyltransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

9 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
cysteine-type peptidase activity Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile.
dioxygenase activity Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products. [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf]
metal ion binding Binding to a metal ion.
mRNA methyltransferase activity Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.
RNA binding Binding to an RNA molecule or a portion thereof.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.
RNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time.

4 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.
viral RNA genome replication The replication of a viral RNA genome.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MALLSRTAAE EVIASFTSEE QSRISTQAVL ALTNVEKDKH DLFNYALPEL AKMRLFNSGI
70 80 90 100 110 120
YLSPHSYRPH SHPVCKTLEN NILFNILPSY LDNSFYLVSI KKNKVDFLKR RHPDLQMVET
130 140 150 160 170 180
INRYISSIDK TRYGGFFHVS PSKISAKFKC DRRTGFEDDA SLIDLIPGCM EGARKRFFFH
190 200 210 220 230 240
DELHYWTKEA LITFLDHVKP EVMLASIVFP PEILAGAKES LNPWCYTFRI VGKDLVFFPD
250 260 270 280 290 300
GEQSEAYIQP VAGSYLLRTG KITTPSGDIF QLDLLKSSFS HHLISITKGE AIGQKMRFFN
310 320 330 340 350 360
GFEAVAMKGL NPLRRKVESC LPISKNTILK IYRYLRTLKK PDLQSAMAKL SQVCKDPNGY
370 380 390 400 410 420
EIKFFEEFSK LCLKCDTLNT NMIPDMKRIV QGFFLKLFPN PISRNFKVVQ QLHLDNFIET
430 440 450 460 470 480
LEEFNFSINT ESLSLNWKDD LEFVNLTFGD TDFNVEDSFA EAWGTKKDVV NITTVHHSPY
490 500 510 520 530 540
LVSKFESYDH QFHSILSVKS ISALTRIAKI VLSLYDPCVV EAFSESRVTN LAVNVIIAAN
550 560 570 580 590 600
LRACFAVTDL WRIFEGILLK ECKRAQGKMR KRFHFELGIR WFLFVDVSNQ WFLPPCRDGL
610 620 630 640 650 660
IARSVSFDQF IKGCQRDNSL HNGRMSLRQV LKGPKLQALF DVSELSIIHN VEMENAPEAG
670 680 690 700 710 720
STLDAGIKPT SSPLEVVPIE NARCNLAPCK CDLNCFIQPA DVNSLHGNLV FLDFIGGSKG
730 740 750 760 770 780
RGASFYSRDL KGYSYTGFSH VSRGWPAFLD KFLSDNKIPL NFYNQCLVQE YSTGHGLSMH
790 800 810 820 830 840
KDDESIYDIN HQVLTVNYSG DAIFCIECLG SGFEIPLSGP QMLLMPFGFQ KEHRHGIKSP
850 860 870 880 890 900
SKGRISLTFR LTKEGDSQVP IQEVVTICDH GDSDDRAALK ALERRSHQSG GRPAVELEGH
910 920 930 940 950 960
EREKVNSDSS DSAPVQEFLI QIDSSLLEYA LKSLSGLSKN VVNCDMCLCN SPWLKNEELR
970 980 990 1000 1010 1020
FSEALRDLAF AQGLIQLIDF LCLKVLRCAE VNRIISELPT HVFPLRGTMH IVDLDDESIR
1030 1040 1050 1060 1070 1080
GDVKEGSFSG FRRWKVMSCS TDLIMLAFLK PKMTLGGELR SHEDECELSD LTEKLHGCSV
1090 1100 1110 1120 1130 1140
ILSRKFEPDL FHSFDVEADG NCFWHSVGPL IGVDGEYLKR ILHDQAKKDG VKCPRLSKQL
1150 1160 1170 1180 1190 1200
EGNTWAEREA VAYFCSHYGI RLNVLYTREE CTWIFKPHEV LKAATLICQD NHFKPCMPVN
1210 1220 1230 1240 1250 1260
GCVIRAISSA LNRREVDVLA VLGKPAHEDL FEEVAEGRGF SIFDLTRLFE IFSICGSVDT
1270 1280 1290 1300 1310 1320
GGELIMVNEN GRIPAEFSLE KEHLAHIPTL SRRKFSPIVS DLNRVSNSAM RFLAINGAEV
1330 1340 1350 1360 1370 1380
DYRPSIDRAS TLLDSFEIGA TGVLCQGIKE AQKDLASKLI PELVHERKLI MILGTFGCGK
1390 1400 1410 1420 1430 1440
SSLFKKFIEK SPGKAITFVS PRRSLAESIN HDLGLARVGG KKTGKSKDLK NVRVKTFELF
1450 1460 1470 1480 1490 1500
ILHLDSIKEG HTVVIDEIQL FPPGYIDLII LGLKPNVNII IAGDPCQSDY DCSSDRHIFA
1510 1520 1530 1540 1550 1560
GSESDIMRIL SGRSYKFNIL SQRFRNPVFY GRLPCNLNKT RLTLDEEEYT LWDSIQEFSM
1570 1580 1590 1600 1610 1620
MGRKDCPVVL VSSFEEKKIV AAHLGLKMKC ITYGESTGLN FQKGAILVTY ESALTSDRRW
1630 1640 1650 1660 1670 1680
WTALSRFSHD IHFINGMGVT WDNAITHFVG KPLHKFFTKR ACNDDIIDLL PGRPELIEGF
1690 1700 1710 1720 1730 1740
QSQVGADEGV REAKLVGDPW LKTKIFLGQN PDFEIEIADE VEAAEDWFKT HIPIMSLEAV
1750 1760 1770 1780 1790 1800
RAQWVHKLIS REDREFRIGD ITTEQFTDDH SKNRGQELTN AAERYEAIYP RHKGTDTATF
1810 1820 1830 1840 1850 1860
LMAVKKRLSF SSPAAEHAKL RRAKPFGKFL LDTFLKRVPL NSSHDEKMMQ EAVHAFEEKK
1870 1880 1890 1900 1910 1920
LSKSMATIEN HSGRSCEDWP VDKALIFMKS QLCTKFDNRF RSAKAGQTLA CFQHSVLCRF
1930 1940 1950 1960 1970 1980
APYMRYIESK VTEVLPKNLY IHSGKNIDDL AAWVTTSKFN GVCTESDYEA FDASQDHFIL
1990 2000 2010 2020 2030 2040
AFELEVMKFL GLPSDLIADY TFIKTHLGSK LGSFAIMRFT GEASTFLFNT MANMLFTFLR
2050 2060 2070 2080 2090 2100
YDLNGREAIC FAGDDMCANS RLKVTNRFSN FLDKIKLKAK VQFTATPTFC GWGLCEHGVF
2110 2120 2130 2140 2150 2160
KKPDLVLERL QIARETRNLE NCIDNYAIEV SCAYKMGENL NLYLTPQEVD AHYNCVRFIV
2170 2180
QHNHLLKSNI RDLFKGESLP ASS