Q64682

PR
Gene name
GRK2
Protein name
Beta-adrenergic receptor kinase 1
Names
Beta-ARK-1, G-protein-coupled receptor kinase 2
Species
Mesocricetus auratus (Golden hamster)
KEGG Pathway
EC number
2.7.11.15: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-61 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

334-355 (Activation loop from InterPro)

Target domain

191-453 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q64682

Entry ID Method Resolution Chain Position Source
AF-Q64682-F1 Predicted AlphaFoldDB

No variants for Q64682

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q64682

No associated diseases with Q64682

4 regional properties for Q64682

Type Name Position InterPro Accession
domain SH2 domain 58 - 158 IPR000980
domain SH3 domain 1 - 58 IPR001452-1
domain SH3 domain 158 - 217 IPR001452-2
domain GRAP, N-terminal SH3 domain 2 - 55 IPR035645

Functions

Description
EC Number 2.7.11.15 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
  • Cell membrane
  • Postsynapse
  • Presynapse
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
anchoring junction A cell junction that mechanically attaches a cell (and its cytoskeleton) to neighboring cells or to the extracellular matrix.
cell projection A prolongation or process extending from a cell, e.g. a flagellum or axon.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
postsynapse The part of a synapse that is part of the post-synaptic cell.
presynapse The part of a synapse that is part of the presynaptic cell.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
beta-adrenergic receptor kinase activity Catalysis of the reaction: ATP + beta-adrenergic receptor = ADP + phospho-beta-adrenergic receptor.
G protein-coupled receptor kinase activity Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate.

3 GO annotations of biological process

Name Definition
negative regulation of relaxation of smooth muscle Any process that stops, prevents or reduces the frequency, rate or extent of relaxation of smooth muscle.
protein phosphorylation The process of introducing a phosphate group on to a protein.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MADLEAVLAD VSYLMAMEKS KATPAARASK KILLPEPSIR SVMQKYLEDR GEVTFEKIFS
70 80 90 100 110 120
QKLGYLLFRD FCLNYLEEAK PLVEFYEEIK KYEKLETEEE RVVRSREIFD SYIMKELLAC
130 140 150 160 170 180
SHPFSKNATE HVQGHLVKKQ VPPDLFQPYI EEICQNLRGD VFQKFIESDK FTRFCQWKNV
190 200 210 220 230 240
ELNIHLTMND FSVHRIIGRG GFGEVYGCRK ADTGKMYAMK CLDKKRIKMK QGETLALNER
250 260 270 280 290 300
IMLSLVSTGD CPFIVCMSYA FRTPDNLSFI LDLMNGGDLH YHLSQHGVFS EADMRSYAAE
310 320 330 340 350 360
IILGLEHMHN RFVVYRDLKP ANILLDEHGH VRISDLGLAC DFSKKKPHAS VGTHGYMAPE
370 380 390 400 410 420
VLQKGVAYDS SADWFSLGCM LFKLLRGHSP FRQHKTKDKH EIDRMTLTMA VELPDSFSPE
430 440 450 460 470 480
LRSLLEGLLQ RDVNRRLGCL GRGAQEVKES PFFRSLDWQM VFLQKYPPPL IPPRGEVNAA
490 500 510 520 530 540
DAFDIGSFDE EDTKGIKLPD SDQELYRNFP LTISERWQQE VAETVFDTIN AETDRLEARK
550 560 570 580 590 600
KAKNKQLGHE EDYALGKDCI MHGYMSKMGN PFLTQWQRRY FYLFPNRLEW RGEGEAPQSL
610 620 630 640 650 660
LTMEEIQSVE ETQIKERKCL LLKIRGGKQF VLQCDSDPEL VQWKKELRDA YREAQQLVQR
670 680
VPKMKNKPRS PVVELSKVPL IQRGSANGL