Q64408
Gene name |
CYP11B1 |
Protein name |
Cytochrome P450 11B1, mitochondrial |
Names |
Aldosterone synthase, CYPXIB1, Cytochrome P450C11, Steroid 11-beta-hydroxylase, CYP11B1 |
Species |
Cavia porcellus (Guinea pig) |
KEGG Pathway |
|
EC number |
1.14.15.4: With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q64408
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q64408-F1 | Predicted | AlphaFoldDB |
No variants for Q64408
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q64408 | |||||
No associated diseases with Q64408
1 regional properties for Q64408
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Cytochrome P450, conserved site | 440 - 449 | IPR017972 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.15.4 | With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial inner membrane | The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| heme binding | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. |
| iron ion binding | Binding to an iron (Fe) ion. |
| steroid 11-beta-monooxygenase activity | Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glucocorticoid biosynthetic process | The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAFRLKSDVR | LAGSWLCLRG | ARALGTRAVT | ASKASVLPFE | VIPQHQGNKR | QRVLQFWKEQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NHDDLHLEMH | QTFQELGPIF | RCDVGSTRIV | AVMLPEDCAR | LHQAESPYPH | RMHLEPWMAY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| REHRRQNLGV | FLLNGPEWLS | NRRWLNPNVL | SPKAVQNLLP | MVDTVARDFS | EALKQKVLQS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AQGSLTMDMQ | PDIHKYTVEV | SNFALFGERL | GLFGCNPSSQ | SLKFIHALEA | VFKTTTQLMF |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LPRSLSRWMR | SQAWKEHFEA | WDYISEYAEN | RIQKKYEELA | RGCSQYNSIV | ANLMLQGNLP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LRAMKANIMD | LVAGSVDTTA | LPLMMTLFEL | ARNPTVQQAL | RQESMATEPN | IYENPQRLRM |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ELPLLWAAIK | ETLRMYPVGL | FLERFLTSPL | VLQNYHIPAG | TLVHLNLYSM | GRNPEVFLSP |
| 430 | 440 | 450 | 460 | 470 | 480 |
| EHYNPQRWLE | NKETYKHLAF | GFGVRQCIGR | RLAEVEMLLF | LHHVLKSFCV | ETAFQEDVKF |
| 490 | |||||
| AYRFVMMPTS | APLLTFRPVS |