Q642Q1

PR
Gene name
uba2-a (sae2-a, uble1b-a)
Protein name
SUMO-activating enzyme subunit 2-A
Names
Ubiquitin-like 1-activating enzyme E1B-A, Ubiquitin-like modifier-activating enzyme 2-A
Species
Xenopus laevis (African clawed frog)
KEGG Pathway
xla:399235
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

518-603 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q642Q1

Entry ID Method Resolution Chain Position Source
AF-Q642Q1-F1 Predicted AlphaFoldDB

No variants for Q642Q1

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q642Q1

No associated diseases with Q642Q1

4 regional properties for Q642Q1

Type Name Position InterPro Accession
domain THIF-type NAD/FAD binding fold 6 - 440 IPR000594
domain Ubiquitin/SUMO-activating enzyme ubiquitin-like domain 450 - 536 IPR028077
domain SUMO-activating enzyme subunit 2, C-terminal domain 547 - 636 IPR032426
active_site Ubiquitin-activating enzyme E1, Cys active site 171 - 179 IPR033127

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
SUMO activating enzyme complex A conserved heterodimeric complex with SUMO activating enzyme activity.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
SUMO activating enzyme activity Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

1 GO annotations of biological process

Name Definition
protein sumoylation The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVIGALPKE VAEAVSASRL LVVGAGGIGC ELLKNLVLTG FTNLDVIDLD TIDVSNLNRQ
70 80 90 100 110 120
FLFQKKHVGR SKAQVAKESV LQFCPDANIT AYHDSIMNPD YNVEFFKQFT MAMNALDNNA
130 140 150 160 170 180
ARNHVNRMCL AAGIPLIESG TAGYLGQVSV IKKGVTECYE CQPKPTQKTF PGCTIRNTPS
190 200 210 220 230 240
EPIHCIVWAK YLFNQLFGEE DADQEVAPDI ADPEAAWDPT KAAERANASN VDGDIKRVST
250 260 270 280 290 300
KQWAKSTGYD PIKLFNKLFR DDIKYLLTMD RLWRKRKPPI PLEWASLHNK ENCSEIQNES
310 320 330 340 350 360
SLLGLKDQKV LNVASYAQLF SKSVETLREQ LREKGDGAEL VWDKDDVPAM DFVTAAANLR
370 380 390 400 410 420
MHIFSMNMKS KFDVKSMAGN IIPAIATTNA VISGLIVLEG LKILSGNTEQ CRTVFLNKQP
430 440 450 460 470 480
NPRKKLLVPC SLDPPNPSCY VCAIKPEVTV KLNVHKVTVQ MLQDKILKEK FAMVAPDVQI
490 500 510 520 530 540
EDGKGTILIS SEAGETDANN HRKISEFGIR NSSQLQADDF LQDYTLMMNI LHSDEMEKDV
550 560 570 580 590 600
DFEVVGDVPE KGPQKPPEES VKNITNGSDD GAQPSTSKAQ DQDDVLIVDS DEESPSSSNA
610 620 630 640
DVGMESASLK RKLPDEEAVS STKRKRIEPP VEEDDDIIAL D