Q64277

PR
Gene name
Bst1 (Bp-3, Bp3, Ly65)
Protein name
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 2
Names
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:12182
EC number
3.2.2.6: Hydrolyzing N-glycosyl compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

120-206 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q64277

Entry ID Method Resolution Chain Position Source
AF-Q64277-F1 Predicted AlphaFoldDB

No variants for Q64277

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q64277

No associated diseases with Q64277

No regional properties for Q64277

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q64277

Functions

Description
EC Number 3.2.2.6 Hydrolyzing N-glycosyl compounds
Subcellular Localization
  • Cell membrane ; Lipid-anchor, GPI-anchor
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
anchored component of membrane The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
uropod A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively.

7 GO annotations of molecular function

Name Definition
ADP-ribosyl cyclase activity Catalysis of the reaction: NAD = cyclic ADP-ribose + nicotinamide.
cyclic ADP-ribose hydrolase Catalysis of the reaction: cyclic ADP-ribose + H20 = ADP-ribose (ADPR).
NAD(P)+ nucleosidase activity Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide.
NAD+ nucleosidase activity Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose.
NAD+ nucleotidase, cyclic ADP-ribose generating Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose that proceeds in a stepwise fashion by ADP-ribosyl cyclase activity followed by cyclic ADP-ribose hydrolase activity.
phosphorus-oxygen lyase activity Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.

8 GO annotations of biological process

Name Definition
positive regulation of B cell proliferation Any process that activates or increases the rate or extent of B cell proliferation.
positive regulation of cell population proliferation Any process that activates or increases the rate or extent of cell proliferation.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of calcium-mediated signaling Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response.
regulation of cell-matrix adhesion Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix.
regulation of inflammatory response Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents.
regulation of neutrophil chemotaxis Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.
regulation of peptidyl-tyrosine phosphorylation Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVQGGLLSL WLWLWLSLLT VLLGARARWR GEGTTPHLQS IFLGRCAEYT TLLSLGNKNC
70 80 90 100 110 120
TAIWEAFKGV LDKDPCSVLP SDYDLFINLS RHPIPRDKSL FWENNHLLVM SYGENTRRLV
130 140 150 160 170 180
ALCDVLYGKV GDFLSWCRQE NASGLDYQSC PTSEDCENNA VDSYWKSASM QYSRDSSGVI
190 200 210 220 230 240
NVMLNGSEPK GAYPTRGFFA DFEIPYLQKD KVTRIEIWVM HDVGGPNVES CGEGSVKILE
250 260 270 280 290 300
DRLEALGFQH SCINDYRPVK FLMCVDHSTH PDCIMNSASA SMRRESASLH AIGDASLLIS
310
LLVALASSSQ A