Q640M1

PR
Gene name
Utp14a (JsdX, Kiaa0266)
Protein name
U3 small nucleolar RNA-associated protein 14 homolog A
Names
Juvenile spermatogonial depletion-like X-linked protein, Jsd-like X-linked protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:72554
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-70 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q640M1

Entry ID Method Resolution Chain Position Source
AF-Q640M1-F1 Predicted AlphaFoldDB

55 variants for Q640M1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs30163574 2 N>S No EVA
rs256869378 4 I>S No EVA
rs223169123 25 N>K No EVA
rs3389557885 35 G>W No EVA
rs3389525143 41 R>* No EVA
rs247170898 44 Q>H No EVA
rs3389562917 58 R>M No EVA
rs3389552125 66 E>D No EVA
rs3389537405 111 K>E No EVA
rs3389552181 143 K>R No EVA
rs260510664 166 S>C No EVA
rs3389558625 176 R>S No EVA
rs3389515628 187 E>D No EVA
rs3410002866 207 V>E No EVA
rs3389568623 222 I>N No EVA
rs3389570383 226 E>* No EVA
rs3389515611 232 A>V No EVA
rs3389558611 260 K>E No EVA
rs3389537449 266 K>N No EVA
rs3410314120 270 Q>H No EVA
rs3410479773 277 D>A No EVA
rs3389562950 300 Q>K No EVA
rs3410361473 314 K>I No EVA
rs3389559180 348 G>D No EVA
rs3389557936 356 V>L No EVA
rs3389558581 369 G>R No EVA
rs3389573274 378 C>Y No EVA
rs3389515546 391 S>A No EVA
rs3389562981 398 A>T No EVA
rs3389507117 412 V>L No EVA
rs3389557895 414 E>K No EVA
rs3389573237 426 R>K No EVA
rs3389558666 436 Q>R No EVA
rs242181689 487 W>R No EVA
rs224470698 507 M>V No EVA
rs3389507181 520 D>G No EVA
rs262555990 527 R>H No EVA
rs233595618 528 P>S No EVA
rs251932643 532 V>E No EVA
rs3409346697 554 M>L No EVA
rs3412693405 614 Q>H No EVA
rs3389570376 624 T>A No EVA
rs3410105366 628 W>R No EVA
rs3389515626 636 L>P No EVA
rs3389554399 656 R>S No EVA
rs225897387 667 S>N No EVA
rs3389507151 669 K>M No EVA
rs3412846730 675 A>E No EVA
rs3389559189 680 R>W No EVA
rs3389562965 698 N>I No EVA
rs3389537466 741 R>W No EVA
rs236574667 747 M>I No EVA
rs3389537461 758 Q>H No EVA
rs3389570391 759 K>* No EVA
rs3389554406 759 K>T No EVA

No associated diseases with Q640M1

2 regional properties for Q640M1

Type Name Position InterPro Accession
domain Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain 154 - 309 IPR006131
domain Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding 4 - 144 IPR006132

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
small-subunit processome A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

1 GO annotations of biological process

Name Definition
rRNA processing Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5TAP6 UTP14C U3 small nucleolar RNA-associated protein 14 homolog C Homo sapiens (Human) PR
Q9BVJ6 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A Homo sapiens (Human) PR
10 20 30 40 50 60
MNSIKATKGL LALSQQDDLM DLTSNYPLSA SEDEGDSDGE RKHQKLLEAI GSLSGKNRWK
70 80 90 100 110 120
LPERSEAGLK VSEFNVSSEG SGEKLALSDL LGPLKPSSSL AAVKKQLSRV KSKKTLELPL
130 140 150 160 170 180
HKREVEQIHR EVAFSKTSQT LSKWDSVVQK NREAEQLVFP LEKEPSSFAP MEHVFREWKA
190 200 210 220 230 240
RTPLEQEVFN LLHKNKQPVT DPLLTPVEKA SLKAMSLEEA KIRRAELQRA RALQSYYEAR
250 260 270 280 290 300
ARRMKKIKSK KYHKIVKKGK AKKALKDFEQ LRKVDPDAAL EELEKMEKAR MMERMSLKHQ
310 320 330 340 350 360
NSGKWAKSKA IMAKYDLEAR QAMQEQLAKN KELTQKLQVV SESEEEGGAD EEEALVPDIV
370 380 390 400 410 420
NEVQKTADGP NPWMLRSCSR DAKENEIQAD SEQLPESAAH EFPENEENDK PVAEEDELLK
430 440 450 460 470 480
ELEKRRSLRK RSELNQAAEP LGNQETKDST SQEVLSELRA LSKKLSKENH LSKKQKKSPA
490 500 510 520 530 540
KAVDLVWEEE PAPEEDEPLL LQRPERMRTL EELEELGKED SLPNKERPRP SVEGEQVRRN
550 560 570 580 590 600
PQNHSKGKNK KEQMISLQNL LTTRTPSVTS LALPTTVEEL EDEGARDQKQ MIKEAFAGDD
610 620 630 640 650 660
VIKEFLKEKR EAIQANKPKA VDLTLPGWGE WGGMNLKPSA RKRRRFLIKA PEGPPRKDKN
670 680 690 700 710 720
LPNVIISEKR NIHAAAHQVR VLPYPFTHHQ QFERTIQNPI GSTWNTQRAF QKLTAPKVVT
730 740 750 760
KPGHIIKPIT AEDVDCRSSP RSDVPVMQSN PKQHSKHQKQ RKKSSIG