Q63603

PR
Gene name
Dock9 (Trg)
Protein name
Dedicator of cytokinesis protein 9
Names
Cdc42 guanine nucleotide exchange factor zizimin-1, Protein TRG
Species
Rattus norvegicus (Rat)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

615-689 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q63603

Entry ID Method Resolution Chain Position Source
AF-Q63603-F1 Predicted AlphaFoldDB

No variants for Q63603

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q63603

No associated diseases with Q63603

4 regional properties for Q63603

Type Name Position InterPro Accession
domain DOCKER domain 186 - 638 IPR027357
domain DOCKER, Lobe A 179 - 314 IPR046769
domain DOCKER, Lobe B 420 - 495 IPR046770
domain DOCKER, Lobe C 530 - 631 IPR046773

Functions

Description
EC Number
Subcellular Localization
  • Endomembrane system
  • Associated with membranes
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
guanyl-nucleotide exchange factor activity Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
small GTPase binding Binding to a small monomeric GTPase.

3 GO annotations of biological process

Name Definition
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
regulation of catalytic activity Any process that modulates the activity of an enzyme.
small GTPase mediated signal transduction The series of molecular signals in which a small monomeric GTPase relays a signal.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
KLSRGHSPLM KKVFDVYLCF LQKHQSEMAL KNVFTALRSL IYKFPSTFYE GRADMCASLC
70 80 90 100 110 120
YEVLKCCNSK LSSIRTEASQ LLYFLMRNNF DYTGKKSFVR THLQVIISLS QLIADVVGIG
130 140 150 160 170 180
GTRFQQSLSI INNCANSDRL IKHTSFSSDV KDLTKRIRTV LMATAQMKEH ENDPEMLVDL
190 200 210 220 230 240
QYSLAKSYAS TPELRKTWLD SMARIHVKNG DLSEAAMCYV HVTALVAEYL TRKEADLALQ
250 260 270 280 290 300
REPPVFPYSH TSCQRKSRGG MFRQGCTAFR VITPNIDEEA SMMEDVGMQD VHFNEDVLME
310 320 330 340 350 360
LLEQCADGLW KAERLRAGLL TSINSSSPSM KSGGTLETTH LYDTLHRPYS KVTEVITRAA
370 380 390 400 410 420
GSWDLLPGGL FGQGFFEDED GKEYIYKEPK LTPLSEISQR LLKLYSDKFG SENVKMIQDS
430 440 450 460 470 480
GKVNPKDLDS KFAYIQVTHV TPFFDEKELQ ERKTEFERCH NIRRFMFEMP FTQTGKRQGG
490 500 510 520 530 540
VEEQCKRRTI LTAIHCFPYV KKRIPVMYQH HTDLNPIEVA IDEMSKKVAE LHQLCSSAEV
550 560 570 580 590 600
DMIKLQLKLQ GSVSVQVNAG PLAYARAFLD DTNTKRYPDN KVKLLKEVFR QFVEACGQAL
610 620 630 640 650 660
AVNERLIKED QLEYQEEMKA NYREIRKELS DIIVPRICPG EDKRATKFPA HLQRHQRDTN
670 680 690 700 710
KHSGSRVDQF ILSCVTLPHE PHVGTCFVMC KLRTTFRANH WFCQAQEEAM GNGREKEPGL