Q62446

PR
Gene name
Fkbp3 (Fkbp25)
Protein name
Peptidyl-prolyl cis-trans isomerase FKBP3
Names
PPIase FKBP3, 25 kDa FK506-binding protein, 25 kDa FKBP, FKBP-25, FK506-binding protein 3, FKBP-3, Immunophilin FKBP25, Rapamycin-selective 25 kDa immunophilin, Rotamase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:30795
EC number
5.2.1.8: Cis-trans isomerases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

41-112 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q62446

Entry ID Method Resolution Chain Position Source
3KZ7 X-ray 195 A A 106-224 PDB
AF-Q62446-F1 Predicted AlphaFoldDB

15 variants for Q62446

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389243690 15 L>M No EVA
rs3403373440 29 L>Q No EVA
rs3389240920 41 H>R No EVA
rs3389238193 78 I>V No EVA
rs3389243641 84 Q>* No EVA
rs3389172988 86 K>N No EVA
rs3389249873 109 P>S No EVA
rs3389172958 116 L>Q No EVA
rs3389240849 119 G>* No EVA
rs13464456 151 T>S No EVA
rs3389237036 173 R>I No EVA
rs3389209521 187 K>R No EVA
rs3389243694 189 R>L No EVA
rs3389255548 220 L>F No EVA
rs3389172980 224 D>V No EVA

No associated diseases with Q62446

2 regional properties for Q62446

Type Name Position InterPro Accession
domain FKBP-type peptidyl-prolyl cis-trans isomerase domain 122 - 224 IPR001179
domain FKBP3, basic tilted helix bundle domain 6 - 76 IPR041200

Functions

Description
EC Number 5.2.1.8 Cis-trans isomerases
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
peptidyl-prolyl cis-trans isomerase activity Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAAAVPQRAW TVEQLRSEQL PKKDIIKFLQ DHGSDSFLAE HKLLGNIKNV AKTANKDHLV
70 80 90 100 110 120
NAYNHLFESK RFKGTETISK VSEQVKNVKL SDDKPKDSKS EETLDEGPPK YTKSILKKGD
130 140 150 160 170 180
KTNFPKKGDV VHCWYTGTLP DGTVFDTNIQ TSSKKKKNAK PLSFKVGVGK VIRGWDEALL
190 200 210 220
TMSKGEKARL EIEPEWAYGK KGQPDAKIPP NTKLIFEVEL VDID