Q62095
Gene name |
Ddx3y (D1Pas1-rs1, Dead2) |
Protein name |
ATP-dependent RNA helicase DDX3Y |
Names |
EC 3.6.4.13 , D1Pas1-related sequence 1 , DEAD box protein 3, Y-chromosomal , DEAD-box RNA helicase DEAD2 , mDEAD2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
mmu:26900 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
203-390 (DEAD box helicase domain) |
Relief mechanism |
|
Assay |
|
Target domain |
413-574 (C-terminal helicase domain) |
Relief mechanism |
|
Assay |
|
Target domain |
203-390 (DEAD box helicase domain);413-574 (C-terminal helicase domain) |
Relief mechanism |
|
Assay |
|
Accessory elements
No accessory elements
References
- Floor SN et al. (2016) "Autoinhibitory Interdomain Interactions and Subfamily-specific Extensions Redefine the Catalytic Core of the Human DEAD-box Protein DDX3", The Journal of biological chemistry, 291, 2412-21
- Zhang ZM et al. (2013) "Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly", Cell reports, 5, 1269-78
Autoinhibited structure
Activated structure
1 structures for Q62095
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q62095-F1 | Predicted | AlphaFoldDB |
16 variants for Q62095
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3412699723 | 42 | P>S | No | EVA | |
| rs3412854196 | 43 | H>L | No | EVA | |
| rs3411907211 | 57 | D>N | No | EVA | |
| rs3412976176 | 178 | I>T | No | EVA | |
| rs3412617409 | 252 | A>T | No | EVA | |
| rs3412289521 | 290 | Y>C | No | EVA | |
| rs3412585907 | 291 | R>P | No | EVA | |
| rs3411334483 | 343 | L>S | No | EVA | |
| rs3412617439 | 372 | K>Q | No | EVA | |
| rs3411334499 | 483 | L>P | No | EVA | |
| rs3410023185 | 488 | S>P | No | EVA | |
| rs3412784235 | 489 | G>E | No | EVA | |
| rs3412673478 | 563 | K>N | No | EVA | |
| rs3412976162 | 569 | W>C | No | EVA | |
| rs3412497038 | 658 | N>T | No | EVA | |
| rs3410023187 | 659 | N>E | No | EVA |
No associated diseases with Q62095
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| nucleoplasm | That part of the nuclear content other than the chromosomes or the nucleolus. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
| P granule | A small cytoplasmic, non-membranous RNA/protein complex aggregate in the primordial germ cells of many higher eukaryotes. |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| ATP hydrolysis activity | Catalysis of the reaction |
| mRNA binding | Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns. |
| RNA helicase activity | Unwinding of an RNA helix, driven by ATP hydrolysis. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| cell differentiation | The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. |
| gamete generation | The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell. |
| negative regulation of gene expression | Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). |
26 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q5W5U4 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Bos taurus (Bovine) | SS |
| Q6GVM6 | DDX3Y | ATP-dependent RNA helicase DDX3Y | Pan troglodytes (Chimpanzee) | SS |
| Q9NQI0 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Homo sapiens (Human) | SS |
| O15523 | DDX3Y | ATP-dependent RNA helicase DDX3Y | Homo sapiens (Human) | SS |
| O00571 | DDX3X | ATP-dependent RNA helicase DDX3X | Homo sapiens (Human) | EV |
| P16381 | D1Pas1 | Putative ATP-dependent RNA helicase Pl10 | Mus musculus (Mouse) | SS |
| Q61496 | Ddx4 | ATP-dependent RNA helicase DDX4 | Mus musculus (Mouse) | SS |
| Q62167 | Ddx3x | ATP-dependent RNA helicase DDX3X | Mus musculus (Mouse) | SS |
| Q99MJ9 | Ddx50 | ATP-dependent RNA helicase DDX50 | Mus musculus (Mouse) | PR |
| Q91VC3 | Eif4a3 | Eukaryotic initiation factor 4A-III | Mus musculus (Mouse) | PR |
| Q9Z1N5 | Ddx39b | Spliceosome RNA helicase Ddx39b | Mus musculus (Mouse) | PR |
| Q9QY15 | Ddx25 | ATP-dependent RNA helicase DDX25 | Mus musculus (Mouse) | PR |
| Q61655 | Ddx19a | ATP-dependent RNA helicase DDX19A | Mus musculus (Mouse) | SS |
| Q501J6 | Ddx17 | Probable ATP-dependent RNA helicase DDX17 | Mus musculus (Mouse) | PR |
| Q8VDW0 | Ddx39a | ATP-dependent RNA helicase DDX39A | Mus musculus (Mouse) | PR |
| Q91VN6 | Ddx41 | Probable ATP-dependent RNA helicase DDX41 | Mus musculus (Mouse) | PR |
| Q61656 | Ddx5 | Probable ATP-dependent RNA helicase DDX5 | Mus musculus (Mouse) | PR |
| Q6GWX0 | DDX4 | Probable ATP-dependent RNA helicase DDX4 | Sus scrofa (Pig) | SS |
| Q2R1M8 | Os11g0599500 | DEAD-box ATP-dependent RNA helicase 52C | Oryza sativa subsp. japonica (Rice) | SS |
| Q6Z4K6 | PL10B | DEAD-box ATP-dependent RNA helicase 52B | Oryza sativa subsp. japonica (Rice) | SS |
| Q75HJ0 | PL10A | DEAD-box ATP-dependent RNA helicase 37 | Oryza sativa subsp. japonica (Rice) | SS |
| O01836 | glh-3 | ATP-dependent RNA helicase glh-3 | Caenorhabditis elegans | PR |
| D0PV95 | laf-1 | ATP-dependent RNA helicase laf-1 | Caenorhabditis elegans | SS |
| Q84W89 | RH37 | DEAD-box ATP-dependent RNA helicase 37 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q8LA13 | RH11 | DEAD-box ATP-dependent RNA helicase 11 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| Q9M2F9 | RH52 | DEAD-box ATP-dependent RNA helicase 52 | Arabidopsis thaliana (Mouse-ear cress) | SS |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MVRVRADLQC | FNPRDYQVEL | LDKATKKNTI | VQLGTGSGKT | FIAVLLLKEY | GVQLFAPLDQ |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GGKRAFFVVE | KVNLVEQQAI | HIEVHTSFKV | GQVHGQTSSG | LWDSKEQCDQ | FMKRHHVVVI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TAQCLLDLIR | HAYLKIEDMC | VLIFDECHHA | LGSQHPYRSI | MVDYKLLKKD | KPVPRVLGLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| ASLIKAKVAP | EKLMEQLKKL | ESAMDSVIET | ASDLVSLSKY | GAKPYEVVII | CKDFEIGCLG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| IPNFDTVIEI | FDETVAFVNT | TTEFHPDLDL | DPRRPIKDSL | KTTRAVFRQL | GPWAAWRTAQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VWEKELGKII | KSQVLPDKTL | RFLNMAKTSM | ITIKRLLEPE | MKKIKSIEAL | RPYVPQRVIR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| LFEILETFNP | EFQKERMKLE | KAEHLSAIIF | VDQRYIAYSL | LLMMRHIKSW | EPKFKFVNPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| YVVGASGRNL | ASSDSQGLHK | RQTEVLRRFH | RNEINCLIAT | SVLEEGVDVK | QCNLVIKFDR |
| 490 | 500 | 510 | 520 | 530 | 540 |
| PLDMRSYVQS | KGRARRAGSR | YVITVEEKDT | AACDSDLKDF | QQIEKILLSR | HRTVNNPIED |
| 550 | 560 | 570 | 580 | 590 | 600 |
| DSDRFEEFDV | DSQMEPYVVE | KTGATLKMST | AIALINRYCS | KLPSDIFTRL | VPHNQIIPIE |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ENGVTKYCAE | LLLPINSPIK | HAIVLKNPMP | NKKTAQMAVA | LEACRQLHLE | GELDDNLLPK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GRESIAKLLE | HIDEEPDEYA | PGIAAKVGSS | KRKQLYDKKI | ARALNESFVE | ADKECFIYAF |
| 730 | 740 | 750 | 760 | 770 | 780 |
| ELERFREAEL | TLNPKRRKFE | DPFNYEYCFG | FLSAKEIPKI | PPFPVFLRQG | NMKVRLIVAP |
| 790 | 800 | 810 | 820 | 830 | 840 |
| KKTTVTAAQL | QEIQLFHNYL | FTQVLQMCKT | GNLEFDGTSN | APLNTLIVPL | NKRKDDMSYT |
| 850 | 860 | 870 | 880 | 890 | 900 |
| INMKYVSEVV | ANMENMPRIP | KDEVRRQYKF | NAEDYKDAIV | MPWYRNLEQP | VFYYVAEILP |
| 910 | 920 | 930 | 940 | 950 | 960 |
| EWRPSSKFPD | THFETFNEYF | IKKYKLEIYD | QNQSLLDVDF | TSTRLNLLQP | RIQNQPRRSR |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TVSNSSTSNI | PQASASDSKE | SNTSVPHSSQ | RQILVPELMD | IHPISATLWN | VIAALPSIFY |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| RVNQLLLTDE | LRETILVKAF | GKEKTKLDDN | VEWNSLAYAT | EYEEKQTIIV | KKIQQLRDLN |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| QKSIEDQERE | TRENDKIDDG | EELFNIGVWD | PEEAVRIGVE | ISSRDDRMDG | EDQDTVGLTQ |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| GLHDGNISDE | DDELPFVMHD | YTARLTSNRN | GIGAWSGSES | IVPSGWGDWD | GPEPDNSPMP |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| FQILGGPGGL | NVQALMADVG | RVFDPSTASS | SLSQTVQEST | VSPPKQLTKE | EEQFKKLQND |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| LLKQAKERLE | ALEMSEDMEK | PRRLEDTVNL | EDYGDDQENQ | EDENTPTNFP | KTIDEEIEEL |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| SIGARKKQEI | DDNAAKTDVL | ERENCEVLPV | AINEKSRSFS | FEKESKAING | RLIRQRSEEY |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| VSHIDSDIGL | GVSPCLLLTA | LTTSNAADGM | SLERFETIGD | SFLKFATTDY | LYHTLLDQHE |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| GKLSFARSKE | VSNCNLYRLG | KKLGIPQLIV | ANKFDAHDSW | LPPCYIPTCD | FKAPNTDDAE |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| EKDNEIERIL | DGQVIEEKPE | NKTGWDIGGD | VSKSTTDGIE | TITFPKQARV | GNDDISPLPY |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| NLLTQQHISD | KSIADAVEAL | IGVHLLTLGP | NPTLKVMNWM | GLKVIQKDQK | SDVPSPLLRF |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| IDTPTNPNAS | LNFLNNLWQQ | FQFTQLEEKI | GYRFKERAYL | VQAFTHASYI | NNRVTGCYQR |
| 1690 | 1700 | 1710 | 1720 | 1730 | 1740 |
| LEFLGDAVLD | YMITRYLFED | SRQYSPGVLT | DLRSALVNNT | IFASLAVKFE | FQKHFIAMCP |
| 1750 | 1760 | 1770 | 1780 | 1790 | 1800 |
| GLYHMIEKFV | KLCSERNFDT | NFNAEMYMVT | TEEEIDEGQE | EDIEVPKAMG | DIFESVAGAI |
| 1810 | 1820 | 1830 | 1840 | 1850 | 1860 |
| YLDSGRNLDT | TWQVIFHMMR | GTIELCCANP | PRSPIRELME | FEQSKVRFSK | MERILESGKV |
| 1870 | 1880 | 1890 | 1900 | ||
| RVTVEVVNNM | RFTGMGRNYR | IAKATAAKRA | LKYLHQIEQQ | RRQSPSLTTV |