Q61XD3

PR
Gene name
air-2 (CBG04030)
Protein name
Aurora/IPL1-related protein kinase 2
Names
Serine/threonine-protein kinase aurora-B
Species
Caenorhabditis briggsae
KEGG Pathway
cbr:CBG_04030
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-48 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

167-188 (Activation loop from InterPro)

Target domain

27-277 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q61XD3

Entry ID Method Resolution Chain Position Source
AF-Q61XD3-F1 Predicted AlphaFoldDB

No variants for Q61XD3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q61XD3

No associated diseases with Q61XD3

3 regional properties for Q61XD3

Type Name Position InterPro Accession
domain Protein kinase domain 27 - 277 IPR000719
active_site Serine/threonine-protein kinase, active site 146 - 158 IPR008271
binding_site Protein kinase, ATP binding site 33 - 56 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm, cytoskeleton
  • Chromosome
  • Midbody
  • Meiotic and mitotic chromosomes
  • During each division, relocates to the midbody microtubules (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
chromosome passenger complex A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.
condensed nuclear chromosome A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
midbody A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis.
spindle microtubule Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole.
spindle midzone The area in the center of the spindle where the spindle microtubules from opposite poles overlap.
spindle pole centrosome A centrosome from which one pole of a mitotic or meiotic spindle is organized.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATPase binding Binding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP.
histone serine kinase activity Catalysis of the transfer of a phosphate group to a serine residue of a histone.
kinesin binding Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.

11 GO annotations of biological process

Name Definition
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
chromosome condensation The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells.
establishment of protein localization The directed movement of a protein to a specific location.
meiotic spindle midzone assembly The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis.
mitotic spindle midzone assembly The cell cycle process in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone.
mitotic spindle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
peptidyl-threonine phosphorylation The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
regulation of actomyosin contractile ring contraction Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle.
regulation of cytokinesis Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MENKPQILQT KSKNTPNKGG KLSINDFEIG RPLGKGKFGS VYLARTKTGH FHCAIKVLFK
70 80 90 100 110 120
SQLISGGVEH QLEREIEIQS HLQHPNIIRL YNYFWDAKKI YLILEYAPGG EMYKQLTTQK
130 140 150 160 170 180
RFTEAMAGKY MYEIADALSY CHRKNVIHRD IKPENLLIGA QGELKIGDFG WSVHAPSNKR
190 200 210 220 230 240
QTMCGTMDYL PPEMVNGNSH SDAVDLWAIG VLCYEFLVGK PPFEHENQAD TYSAIKAGRF
250 260 270 280 290 300
TYPDFVKKGA RDLIGKLLVV DPRRRCSLQE VKDHYWVTSM LDSCRRAAEK QKAERAASLR
DH