Q61WR2

PR
Gene name
tag-151 (CBG04291)
Protein name
Pre-rRNA-processing protein TSR1 homolog
Names
Species
Caenorhabditis briggsae
KEGG Pathway
cbr:CBG_04291
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-88 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61WR2

Entry ID Method Resolution Chain Position Source
AF-Q61WR2-F1 Predicted AlphaFoldDB

No variants for Q61WR2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q61WR2

No associated diseases with Q61WR2

3 regional properties for Q61WR2

Type Name Position InterPro Accession
domain Ribosome biogenesis protein BMS1/TSR1, C-terminal 457 - 753 IPR007034
domain AARP2CN 229 - 310 IPR012948
domain Bms1/Tsr1-type G domain 83 - 243 IPR030387

Functions

Description
EC Number
Subcellular Localization
  • Nucleus, nucleolus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
nucleolus A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.
preribosome, small subunit precursor A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit.

3 GO annotations of molecular function

Name Definition
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
U3 snoRNA binding Binding to a U3 small nucleolar RNA.

2 GO annotations of biological process

Name Definition
endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae.
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTTGHRAGV FKKPAKPHKS WKGKRTKGEI TTENRGREGV KQLTRSAHST HRAVSKDARR
70 80 90 100 110 120
NQLKMARDRK MADAMERRRT SNAPCLVTIL SLGVGARPSE FLKKLATCDE TIVQTHSPST
130 140 150 160 170 180
IDFAIPRFKS RISFLTPDKE NVDSVLDAIR ASDVLCFLWP LSAELSEWDE QLLTICKAAG
190 200 210 220 230 240
LPTIVSVVPG LGGIQNHKKK EDVRKGIEFT ISKWSMSNAG VMPADSVTDN LQLLRTLNET
250 260 270 280 290 300
KKKPLTLQAR HSYMLVENLE ATESPEDSSK ITLKAQGYLR GPEWNANNLI HLPGFGDFQI
310 320 330 340 350 360
SKIETAADPH PLKTSPPKGA EVIAKADEKR QSLETEITLD AMDGEQTWPT QEELEEADKE
370 380 390 400 410 420
MRRVPKGTSS YQAAWILDDS EDDEDEEDED EDMDDEEEDK DLEEDDEEED TPMDLKSEAG
430 440 450 460 470 480
ETTASEMMFH DEIDEDINLA EVEKYRKERE NAQWPDEVDT PIDQPARIRF QKYRGLKSFR
490 500 510 520 530 540
TSTWDAKENL PVDYARIFQF ANYKNTKKNV MSKIGGNDVD AGDAVIDKKF NGVFASVYIE
550 560 570 580 590 600
NVPVSVMEAY KETKNLVLFQ LLPHEQKMSI LNMVLKKHPS CTVPIGSEDQ KFIFYVGFRQ
610 620 630 640 650 660
FEAHAVLSSN TPGDKFKLER FMPTEKTFVA TVYAPITFNP ATVLCFRQDD KGRQELVATG
670 680 690 700 710 720
SVLDTNPDRI VLKRTVLSGH PYKINRRAVV VRYMFFNRED IDWFKPVELY TPSGRRGHIK
730 740 750 760 770 780
EAVGTHGHMK CRFDQQLNAQ DSVMLNLYKR VFPVWDYSLF NRNLNPSRFV ERSRVESISL
VQEDAMEE