Q61UC4

PR
Gene name
lin-45
Protein name
Raf homolog serine/threonine-protein kinase
Names
Abnormal cell lineage protein 45
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-161 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

618-645 (Activation loop from InterPro)

Target domain

479-746 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q61UC4

Entry ID Method Resolution Chain Position Source
AF-Q61UC4-F1 Predicted AlphaFoldDB

No variants for Q61UC4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q61UC4

No associated diseases with Q61UC4

11 regional properties for Q61UC4

Type Name Position InterPro Accession
domain BRCT domain 638 - 719 IPR001357
domain Helix-hairpin-helix DNA-binding motif, class 1 511 - 530 IPR003583-1
domain Helix-hairpin-helix DNA-binding motif, class 1 543 - 562 IPR003583-2
domain Helix-hairpin-helix DNA-binding motif, class 1 592 - 611 IPR003583-3
domain Zinc-finger, NAD-dependent DNA ligase C4-type 429 - 455 IPR004149
domain NAD-dependent DNA ligase, OB-fold 333 - 419 IPR004150
domain NAD-dependent DNA ligase, adenylation 13 - 328 IPR013839
domain NAD-dependent DNA ligase, N-terminal 13 - 469 IPR013840
active_site NAD-dependent DNA ligase, active site 127 - 156 IPR018239
conserved_site NAD-dependent DNA ligase, conserved site 341 - 356 IPR033136
domain DisA/LigA, helix-hairpin-helix motif 541 - 578 IPR041663

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
MAP kinase kinase kinase activity Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases.
metal ion binding Binding to a metal ion.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

4 GO annotations of biological process

Name Definition
MAPK cascade An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell.
meiotic cell cycle Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions.
oogenesis The complete process of formation and maturation of an ovum or female gamete from a primordial female germ cell. Examples of this process are found in Mus musculus and Drosophila melanogaster.
protein phosphorylation The process of introducing a phosphate group on to a protein.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSRINLKKSS AATTPTSPHC PSPRLISLPR CASSSIDRKD QGSPMASPST PLYPKHSDSL
70 80 90 100 110 120
HSLSGHDHSG VGTSDKEPPK FKYKMIMVHL PFDQHSRVEV RPGETARDAI SKLLKKRNIT
130 140 150 160 170 180
PQLCQVNTSP DSKTEAIDLS KTMEEIALHL PDNELWVHSE YLNTVSSIKH AIVRRTFIPP
190 200 210 220 230 240
KSCDVCNNPI WMMGFRCEFC QFKFHQRCSS FAPLYCDLLQ SVPKNEDLVK QLVGIASEND
250 260 270 280 290 300
GPDRSVAEIV LAGLAPTYGQ SPAATPDSSH PDLTSIKRTG GVKRHPLAVS PQAETAQLSP
310 320 330 340 350 360
AGPYPRDRSS SAPNINAIND EATVQHNQRI LDALEAKRLE EESKDKTGSL LSTQARRPHC
370 380 390 400 410 420
YSGHILSGSR MNRLHPLVDC TPLGSNSPSS TCSSPPGGLM GPTLLGQSSS VSGSTTSSLV
430 440 450 460 470 480
AAHLHTLPLT PPQSAPPQKI SPGFFRNRSR SPGERIEAQR PRPPQKPQHE DWEILPNEFV
490 500 510 520 530 540
IHYKVGSGSF GTVYRGEFFG TVAIKKLNVV DPTPSQMAAF KNEVAVLKKT RHLNVLLFMG
550 560 570 580 590 600
WVREPEIAII TQWCEGSSLY RHIHVQEPRV EFEMSAVIDI LKQVSLGMNY LHSKNIIHRD
610 620 630 640 650 660
LKTNNIFLMD DMSTVKIGDF GLATVKTKWT VNGGQQQQQP TGSILWMAPE VIRMQDDNPY
670 680 690 700 710 720
TPQSDVYSFG VCMYEILSSH LPYSNINNRD QILFMVGRGY LKPDRSKIRT DTPKSLMKLY
730 740 750 760 770 780
DNCIMFDRNE RPVFGEVLER LRDIILPKLT RSQSAPNVLH YDSQYSVMDA VMRSQMVSSS
790 800 810
YIPPSTAKTP QSAAAAAAAN KKAYYNVYGL I