Q61AP6

PR
Gene name
sta-1
Protein name
Signal transducer and activator of transcription 1
Names
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

28-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61AP6

Entry ID Method Resolution Chain Position Source
AF-Q61AP6-F1 Predicted AlphaFoldDB

No variants for Q61AP6

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q61AP6

No associated diseases with Q61AP6

3 regional properties for Q61AP6

Type Name Position InterPro Accession
domain SH2 domain 477 - 536 IPR000980
domain STAT transcription factor, all-alpha domain 11 - 181 IPR013800
domain STAT transcription factor, DNA-binding 204 - 356 IPR013801

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Nucleus
  • Translocated into the nucleus in response to phosphorylation
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

2 GO annotations of molecular function

Name Definition
DNA-binding transcription factor activity, RNA polymerase II-specific A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II.
RNA polymerase II cis-regulatory region sequence-specific DNA binding Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II.

4 GO annotations of biological process

Name Definition
defense response Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack.
receptor signaling pathway via JAK-STAT Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
regulation of cell population proliferation Any process that modulates the frequency, rate or extent of cell proliferation.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MMGSSSQELQ TALTDISKTC HHMWEDSKDL QGRFVNDLAE LQRLQCTITN FERAQHPEQA
70 80 90 100 110 120
FQAKQAMTEM QKKATGVYEM LAQRRNEIIS KLNDGANIAS MMQGQLINDK LFTWKNAQKL
130 140 150 160 170 180
AQIGMPFDDR EQLLDEIQLE FEFLADNIWQ LNMFACWMCD LCRRAPQLND GLAQSSAAKL
190 200 210 220 230 240
TTISEQLNRL LFVLVSQSFI VSVQPEPVLK TQHKFVTEVR LLIGDKLGIR QQLMNTNVSV
250 260 270 280 290 300
KIIAEDEARV MSVDCDAQKE IRANKQVGSI SNDFEKLTMD ERGHLSAKFN NSKLTRIAHR
310 320 330 340 350 360
KPPPKGASDM KCAANMQAAT DQKYALLFFI TPFQMGNLSK EEQLDVWTLS LPIMVTVHGS
370 380 390 400 410 420
QDCDAQVAIL WHRAFASISR DPNVHDVTAV SWENLAIMLR NKFSLFTGAR RPLSESDLAY
430 440 450 460 470 480
LSEKIIIPNM PDQKPITFTR FAKQAMREEL AFSFWEWFFS IMQLIKQKLL KYWDEGWCIG
490 500 510 520 530 540
FISKHDASQS MCMLPNTSFL LRFSDTQTGA VSIGFVCQDD DGQKVPFHLS PLTIKDLDQL
550 560 570 580 590 600
SLASRIASCP QLKDIRYMYP NIDKEEMLRY FESEERHRVG GPESPGGYIQ SEIVMVAKTN
610 620 630 640 650 660
GNFRRASAAP SMFGADSPSP LSIQSKLDWS PGEIHQSMME MTDELGHVLN VGGMDSMHPD
670 680 690 700 710
ANTLLGPAFK NPTFHPHDQQ QHLQFVDMSH PQMMQQQHHG HNHNHTHNQF YPS