Q61823

PR
Gene name
Pdcd4 (Ma3, Tis)
Protein name
Programmed cell death protein 4
Names
Protein MA-3, Topoisomerase-inhibitor suppressed protein
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:18569
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

31-128 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for Q61823

Entry ID Method Resolution Chain Position Source
2HM8 NMR - A 319-449 PDB
2IOL X-ray 200 A A/B 320-469 PDB
2ION X-ray 157 A A 320-467 PDB
2IOS X-ray 176 A A 320-469 PDB
2KZT NMR - B 319-449 PDB
2NSZ X-ray 115 A A 322-450 PDB
3EIQ X-ray 350 A C 120-469 PDB
AF-Q61823-F1 Predicted AlphaFoldDB

5 variants for Q61823

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3389546417 35 E>K No EVA
rs3389555973 194 G>E No EVA
rs3389513837 252 L>M No EVA
rs3389561488 289 V>I No EVA
rs3389494978 466 P>T No EVA

1 associated diseases with Q61823

Without disease ID

2 regional properties for Q61823

Type Name Position InterPro Accession
domain Initiation factor eIF-4 gamma, MA3 163 - 284 IPR003891-1
domain Initiation factor eIF-4 gamma, MA3 326 - 449 IPR003891-2

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Shuttles between the nucleus and cytoplasm (PubMed:12894233)
  • Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
RNA binding Binding to an RNA molecule or a portion thereof.

17 GO annotations of biological process

Name Definition
apoptotic process A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
BMP signaling pathway The series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
cellular response to lipopolysaccharide Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.
epithelial to mesenchymal transition involved in cardiac fibroblast development A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will mature into a cardiac fibroblast.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
negative regulation of cytokine production involved in inflammatory response Any process that stops, prevents or reduces the frequency, rate or extent of cytokine production involved in inflammatory response.
negative regulation of DNA-templated transcription Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription.
negative regulation of JUN kinase activity Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity.
negative regulation of myofibroblast differentiation Any process that stops, prevents or reduces the frequency, rate or extent of myofibroblast differentiation.
negative regulation of vascular associated smooth muscle cell differentiation Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell differentiation.
negative regulation of vascular associated smooth muscle cell proliferation Any process that stops, prevents or reduces the frequency, rate or extent of vascular smooth muscle cell proliferation.
positive regulation of endothelial cell apoptotic process Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process.
positive regulation of inflammatory response Any process that activates or increases the frequency, rate or extent of the inflammatory response.
positive regulation of NIK/NF-kappaB signaling Any process that activates or increases the frequency, rate or extent of NIK/NF-kappaB signaling.
positive regulation of smooth muscle cell apoptotic process Any process that activates or increases the frequency, rate, or extent of smooth muscle cell apoptotic process.
positive regulation of vascular associated smooth muscle cell apoptotic process Any process that activates or increases the frequency, rate or extent of vascular associated smooth muscle cell apoptotic process.
regulation of protein metabolic process Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q53EL6 PDCD4 Programmed cell death protein 4 Homo sapiens (Human) PR
10 20 30 40 50 60
MDIENEQTLN VNPTDPDNLS DSLFSGDEEN AGTEEIKNEI NGNWISASTI NEARINAKAK
70 80 90 100 110 120
RRLRKNSSRD SGRGDSVSDN GSEAVRSGVA VPTSPKGRLL DRRSRSGKGR GLPKKGGAGG
130 140 150 160 170 180
KGVWGTPGQV YDVEEVDVKD PNYDDDQENC VYETVVLPLD ETAFEKTLTP IIQEYFEHGD
190 200 210 220 230 240
TNEVAEMLRD LNLGEMKSGV PVLAVSLALE GKASHREMTS KLLSDLCGTV MSTNDVEKSF
250 260 270 280 290 300
DKLLKDLPEL ALDTPRAPQL VGQFIARAVG DGILCNTYID SYKGTVDCVQ ARAALDKATV
310 320 330 340 350 360
LLSMSKGGKR KDSVWGSGGG QQPVNHLVKE IDMLLKEYLL SGDISEAEHC LKELEVPHFH
370 380 390 400 410 420
HELVYEAIVM VLESTGESAF KMILDLLKSL WKSSTITIDQ MKRGYERIYN EIPDINLDVP
430 440 450 460
HSYSVLERFV EECFQAGIIS KQLRDLCPSR GRKRFVSEGD GGRLKPESY