Q61749
PR
Gene name |
Eif2b4 (Eif2b, Eif2bd, Jgr1a) |
Protein name |
Translation initiation factor eIF-2B subunit delta |
Names |
eIF-2B GDP-GTP exchange factor subunit delta |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:13667 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61749
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61749-F1 | Predicted | AlphaFoldDB |
27 variants for Q61749
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3388755696 | 8 | V>I | No | EVA | |
| rs3388751918 | 28 | G>W | No | EVA | |
| rs3388734185 | 43 | K>R | No | EVA | |
| rs3388752481 | 63 | A>D | No | EVA | |
| rs3388741882 | 67 | A>G | No | EVA | |
| rs3388757974 | 68 | Q>L | No | EVA | |
| rs3388757992 | 75 | E>K | No | EVA | |
| rs3388734205 | 108 | Q>H | No | EVA | |
| rs3388757995 | 132 | S>N | No | EVA | |
| rs3388734250 | 152 | D>E | No | EVA | |
| rs3413068861 | 197 | M>K | No | EVA | |
| rs3388757973 | 218 | G>V | No | EVA | |
| rs3388752782 | 222 | G>V | No | EVA | |
| rs3388723789 | 230 | L>V | No | EVA | |
| rs3388752420 | 276 | N>Y | No | EVA | |
| rs249528050 | 290 | S>N | No | EVA | |
| rs257106128 | 305 | L>I | No | EVA | |
| rs3388734235 | 306 | D>Y | No | EVA | |
| rs3395044214 | 310 | Q>P | No | EVA | |
| rs3395409423 | 311 | E>D | No | EVA | |
| rs32437779 | 382 | V>I | No | EVA | |
| rs3388723864 | 400 | S>Y | No | EVA | |
| rs3395497182 | 416 | M>L | No | EVA | |
| rs3412916535 | 439 | C>R | No | EVA | |
| rs3388748923 | 457 | E>* | No | EVA | |
| rs3388752476 | 467 | K>M | No | EVA | |
| rs3388753237 | 502 | I>F | No | EVA |
No associated diseases with Q61749
No regional properties for Q61749
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q61749 | |||
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| eukaryotic translation initiation factor 2B complex | A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| guanyl-nucleotide exchange factor activity | Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions. |
| translation initiation factor activity | Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. |
| translation initiation factor binding | Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation. |
9 GO annotations of biological process
| Name | Definition |
|---|---|
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| negative regulation of guanyl-nucleotide exchange factor activity | Any process that stops, prevents or reduces the frequency, rate or extent of guanyl-nucleotide exchange factor activity. |
| oligodendrocyte development | The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system. |
| ovarian follicle development | The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure. |
| response to glucose | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus. |
| response to heat | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism. |
| response to peptide hormone | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. |
| T cell receptor signaling pathway | The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. |
| translational initiation | The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. |
3 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q3T058 | EIF2B4 | Translation initiation factor eIF-2B subunit delta | Bos taurus (Bovine) | PR |
| Q9UI10 | EIF2B4 | Translation initiation factor eIF-2B subunit delta | Homo sapiens (Human) | PR |
| Q63186 | Eif2b4 | Translation initiation factor eIF-2B subunit delta | Rattus norvegicus (Rat) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAAVAVAVRE | ESRSEMKTEL | SPRPGAAGRE | LTQEEKLQLR | KEKKQQKKKR | KEEKGADQEI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GSAVSAAQRQ | DPIRELPGPG | SQLGGTAGEK | LPAGRSKAEL | RAERRAKQEA | ERALKQARKG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EQGGVPPQAC | PSTAGETTSG | VKRVPEHTPA | DDPTLLRRLL | RKPDRQQVPT | RKDYGSKVSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FSHLPQYSRQ | SSLTQYMSIP | SSVIHPAMVR | LGLQYSQGLI | SGSNARCIAL | LHALQQVIQD |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YTTPPSEELS | RDLVNKLKPY | ISFLTQCRPM | SASMCNAIKF | LTKEVTGMSS | SKREEEAKSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LREALDRYVQ | EKIVLAAQAI | SRFASTKISD | GDVILVYGCS | SLVSRILQEA | RVEGRRFRVV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| VVDSRPRLEG | RHMLHSLVRA | GVPTSYLLIP | AASYVLPEVS | KVLLGAHALL | ANGSVMSRVG |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TAQLALVARA | HNVPVLVCCE | TYKFCERVQT | DAFVSNELDD | PDDLQCKRGD | QVALANWQSH |
| 490 | 500 | 510 | 520 | ||
| PSLRLLNLVY | DVTPPELVDL | VITELGMIPC | SSVPVVLRVK | SSDQ |