Q61425

PR
Gene name
Hadh (Hadhsc, Mschad, Schad)
Protein name
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Names
HCDH, Medium and short-chain L-3-hydroxyacyl-coenzyme A dehydrogenase, Short-chain 3-hydroxyacyl-CoA dehydrogenase
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:15107
EC number
1.1.1.35: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-49 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q61425

Entry ID Method Resolution Chain Position Source
AF-Q61425-F1 Predicted AlphaFoldDB

20 variants for Q61425

Variant ID(s) Position Change Description Diseaes Association Provenance
rs3388667897 23 K>* No EVA
rs3388659952 54 V>I No EVA
rs3388660985 56 V>* No EVA
rs3388651602 57 D>E No EVA
rs3388660988 58 Q>* No EVA
rs3388663221 58 Q>R No EVA
rs3388662650 60 E>G No EVA
rs3388657704 68 K>* No EVA
rs3388663284 105 D>V No EVA
rs3388668469 149 S>T No EVA
rs3388659497 153 I>F No EVA
rs3388667851 161 T>I No EVA
rs3388665058 171 F>L No EVA
rs3388660818 190 S>N No EVA
rs223933025 231 V>I No EVA
rs3393712655 234 H>R* No EVA
rs3388657738 237 G>S No EVA
rs3388653643 250 L>M No EVA
rs3388657675 281 E>G No EVA
rs3388651606 306 T>I No EVA

No associated diseases with Q61425

9 regional properties for Q61425

Type Name Position InterPro Accession
domain Helicase, C-terminal 415 - 577 IPR001650
conserved_site SEC-C motif 821 - 839 IPR004027
domain SecA DEAD-like, N-terminal 5 - 383 IPR011115
domain SecA Wing/Scaffold 571 - 779 IPR011116
domain SecA, preprotein cross-linking domain 227 - 339 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 87 - 245 IPR014001
domain SecA motor DEAD 1 - 571 IPR014018
conserved_site SecA conserved site 481 - 496 IPR020937
domain SecA, C-terminal helicase domain 401 - 541 IPR044722

Functions

Description
EC Number 1.1.1.35 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
  • Mitochondrion matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial matrix The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
nucleoplasm That part of the nuclear content other than the chromosomes or the nucleolus.

3 GO annotations of molecular function

Name Definition
3-hydroxyacyl-CoA dehydrogenase activity Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+).
identical protein binding Binding to an identical protein or proteins.
NAD+ binding Binding to the oxidized form, NAD, of nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions.

7 GO annotations of biological process

Name Definition
fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).
negative regulation of insulin secretion Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of insulin.
positive regulation of cold-induced thermogenesis Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis.
regulation of insulin secretion Any process that modulates the frequency, rate or extent of the regulated release of insulin.
response to activity Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus.
response to insulin Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.
response to xenobiotic stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q16836 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MAFVTRQFLR SMSSSSSASA AAKKILIKHV TVIGGGLMGA GIAQVAAATG HTVVLVDQTE
70 80 90 100 110 120
DILAKSKKGI EESLKRMAKK KFTENPKAGD EFVEKTLSCL STSTDAASVV HSTDLVVEAI
130 140 150 160 170 180
VENLKLKNEL FQRLDKFAAE HTIFASNTSS LQITNIANAT TRQDRFAGLH FFNPVPMMKL
190 200 210 220 230 240
VEVIKTPMTS QKTFESLVDF CKTLGKHPVS CKDTPGFIVN RLLVPYLIEA VRLHERGDAS
250 260 270 280 290 300
KEDIDTAMKL GAGYPMGPFE LLDYVGLDTT KFILDGWHEM EPENPLFQPS PSMNNLVAQK
310
KLGKKTGEGF YKYK