Q61190

PR
Gene name
Il10rb (Crfb4)
Protein name
Interleukin-10 receptor subunit beta
Names
Species
Mus musculus (Mouse)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

262-349 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q61190

Entry ID Method Resolution Chain Position Source
6WEO X-ray 260 A 0/3/6/9/C/E/H/K/O/R/U/X 20-220 PDB
AF-Q61190-F1 Predicted AlphaFoldDB

No variants for Q61190

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q61190

No associated diseases with Q61190

3 regional properties for Q61190

Type Name Position InterPro Accession
domain Fibronectin type III 20 - 111 IPR003961-1
domain Fibronectin type III 112 - 215 IPR003961-2
domain Interferon/interleukin receptor domain 111 - 212 IPR015373

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
cytokine receptor activity Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.
interleukin-10 receptor activity Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.

4 GO annotations of biological process

Name Definition
cytokine-mediated signaling pathway The series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
positive regulation of cellular respiration Any process that activates or increases the frequency, rate or extent of cellular respiration.
positive regulation of receptor signaling pathway via JAK-STAT Any process that activates or increases the frequency, rate or extent of the JAK-STAT signaling pathway activity.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q08334 IL10RB Interleukin-10 receptor subunit beta Homo sapiens (Human) PR
Q8CGK5 Ifnlr1 Interferon lambda receptor 1 Mus musculus (Mouse) PR
10 20 30 40 50 60
MAPCVAGWLG GFLLVPALGM IPPPEKVRMN SVNFKNILQW EVPAFPKTNL TFTAQYESYR
70 80 90 100 110 120
SFQDHCKRTA STQCDFSHLS KYGDYTVRVR AELADEHSEW VNVTFCPVED TIIGPPEMQI
130 140 150 160 170 180
ESLAESLHLR FSAPQIENEP ETWTLKNIYD SWAYRVQYWK NGTNEKFQVV SPYDSEVLRN
190 200 210 220 230 240
LEPWTTYCIQ VQGFLLDQNR TGEWSEPICE RTGNDEITPS WIVAIILIVS VLVVFLFLLG
250 260 270 280 290 300
CFVVLWLIYK KTKHTFRSGT SLPQHLKEFL GHPHHSTFLL FSFPPPEEAE VFDKLSIISE
310 320 330 340
ESEGSKQSPE DNCASEPPSD PGPRELESKD EAPSPPHDDP KLLTSTSEV