Q61127
Gene name |
Nab2 |
Protein name |
NGFI-A-binding protein 2 |
Names |
EGR-1-binding protein 2 |
Species |
Mus musculus (Mouse) |
KEGG Pathway |
mmu:17937 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q61127
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q61127-F1 | Predicted | AlphaFoldDB |
25 variants for Q61127
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs3389132133 | 64 | Q>* | No | EVA | |
| rs3389138662 | 64 | Q>H | No | EVA | |
| rs3389143779 | 98 | R>H | No | EVA | |
| rs3389143762 | 103 | L>Q | No | EVA | |
| rs3389125839 | 108 | T>N | No | EVA | |
| rs3389143828 | 128 | F>Y | No | EVA | |
| rs3389121896 | 140 | S>I | No | EVA | |
| rs3389132144 | 161 | K>Q | No | EVA | |
| rs3389105832 | 163 | P>S | No | EVA | |
| rs3412691979 | 193 | S>F | No | EVA | |
| rs3389134806 | 202 | E>G | No | EVA | |
| rs230056366 | 222 | V>A | No | EVA | |
| rs3389125918 | 223 | G>S | No | EVA | |
| rs3389132300 | 305 | L>M | No | EVA | |
| rs3389135755 | 381 | E>D | No | EVA | |
| rs3389132105 | 381 | E>K | No | EVA | |
| rs3389138701 | 389 | E>A | No | EVA | |
| rs3389143781 | 398 | E>G | No | EVA | |
| rs3389134783 | 402 | P>A | No | EVA | |
| rs3401752853 | 410 | E>* | No | EVA | |
| rs3389098897 | 431 | P>S | No | EVA | |
| rs3389105809 | 436 | P>L | No | EVA | |
| rs3389132362 | 464 | L>M | No | EVA | |
| rs3389121907 | 499 | C>F | No | EVA | |
| rs218732834 | 510 | E>A | No | EVA |
No associated diseases with Q61127
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| identical protein binding | Binding to an identical protein or proteins. |
| transcription coregulator activity | A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| endochondral ossification | Replacement ossification wherein bone tissue replaces cartilage. |
| myelination | The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier. |
| negative regulation of transcription by RNA polymerase III | Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III. |
| positive regulation of tau-protein kinase activity | Any process that activates or increases the frequency, rate or extent of tau-protein kinase activity. |
| regulation of DNA-templated transcription | Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. |
| regulation of epidermis development | Any process that modulates the frequency, rate or extent of epidermis development. |
| Schwann cell differentiation | The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHRAPSPTAE | QPPGRGDNTR | RTPQPRFKAS | APAMALPRTL | GELQLYRVLQ | RANLLSYYET |
| 70 | 80 | 90 | 100 | 110 | 120 |
| FIQQGGDDVQ | QLCEAGEEEF | LEIMALVGMA | TKPLHVRRLQ | KALREWATNP | GLFSQPVPAV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PVSSIPLFKI | SETAGTRKGS | MSNGHGSPGE | KAGSARSFSP | KSPLELGEKL | SPLPGGPGAG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DPRIWPGQST | PESDVGAGGE | EEAGSPPFSP | PAGGGVSEGP | GVGGVAAGGA | GGGPDRLEPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MVRMVVESVE | RIFRSFPRGD | TGEIASLLKL | NKKLARSVGH | IFEMDDHDAQ | KEEEIRKYSV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| IYGRLDSKRR | EGKQLSLHEL | TINEAAAQFC | MRDNTLLLRR | VELFSLSRQV | ARESTYLSSL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KGSRLHSEEL | GGPPLKKLKQ | EVGEQSHNEI | QQPPPGPESY | APPYRPSLEE | DSASLSGESL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| DGHLQAVGSC | PRLTPPPADL | PLALPAHGLW | SRHILQQTLM | DEGLRLARLV | SHDRVGRLSP |
| 490 | 500 | 510 | 520 | ||
| CVPAKPPLAE | FEEGLLDRCP | APGPHPALVE | GRRSSVKVEA | EASRQ |