Q60V90

PR
Gene name
hst-1 (CBG19653)
Protein name
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Names
Glucosaminyl N-deacetylase/N-sulfotransferase 1
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.8.2.8: Sulfotransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

6-100 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60V90

Entry ID Method Resolution Chain Position Source
AF-Q60V90-F1 Predicted AlphaFoldDB

No variants for Q60V90

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q60V90

No associated diseases with Q60V90

2 regional properties for Q60V90

Type Name Position InterPro Accession
domain Sulfotransferase domain 584 - 829 IPR000863
domain Heparan sulphate-N-deacetylase 76 - 492 IPR021930

Functions

Description
EC Number 2.8.2.8 Sulfotransferases
Subcellular Localization
  • Golgi apparatus membrane ; Single-pass type II membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
Golgi apparatus A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways.
Golgi membrane The lipid bilayer surrounding any of the compartments of the Golgi apparatus.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

2 GO annotations of molecular function

Name Definition
[heparan sulfate]-glucosamine N-sulfotransferase activity Catalysis of the reaction: 3'-phosphoadenylyl sulfate
deacetylase activity +Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.

2 GO annotations of biological process

Name Definition
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan.
heparin biosynthetic process The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIITPYLNPR LVKPLKWLAI IILLYFLYFS LFSINKKPGK PRKPPKAVEN YTCPFEKADF
70 80 90 100 110 120
SNFKDKKLEF HKNNGTDPKI LVILDSLFSR HGKSIIQILN SQKFAFKAEA ISKNLPVLTS
130 140 150 160 170 180
AKRGKYSLII VENYYKYLNM ARWNRQLLDK YCKEYRVPLF SFIASKPNDQ LKRIRIKGSS
190 200 210 220 230 240
LWMWQNQRIN RLTVSPSPIH KISKIGAYRN LTTQESDWIL FEISENFESI LTGTVKNGYE
250 260 270 280 290 300
RAVVLRDLGR EDGVEKVIFG RNLTDFQIKI TFLDALWWAM GDEKLFGLDR FVQVDIDDVF
310 320 330 340 350 360
VGAQSTRIVE EDVRHLISAQ NHFRNFIENF KFLLGFSGSY FRNGDDFEDR GDEILIENAE
370 380 390 400 410 420
KFVWFPHMWR HNHAHEHNFT YLESIMVQNR LFAQNMHLPI DYPYAIAPQH DGVFPVHEQM
430 440 450 460 470 480
YEAWKKIWNV TVTATEEYPH LKPATGRKGF IHSGIHVLPR QTCGLYTHTQ FFDEYPEGFQ
490 500 510 520 530 540
KVIKSIQGGD LFFTILLNPI SIFMTHQQNY AHDRLALYTF ENLFRFLNCW TNIRLKWQSP
550 560 570 580 590 600
VESAKMYFEK FPEERIPLWT NPCSDPRHQA ILPPSMSCSK KSLPDLLIIG PQKTGSTALA
610 620 630 640 650 660
SFLALHPNVS QNMEIPGSFE EIQFFSGQNY LKGVEWYMSK FPNETTVIFE KSATYFDNPS
670 680 690 700 710 720
AARQAAAMVP HAKLVIILQN PTQRAYSWFQ SLFQHLIAHK DPIAMSSESL DVILNSTSSE
730 740 750 760 770 780
SAKFKIRQRC LSGGRYVHHL DKWLEHFSLQ QIQFIDSDEL RKEPAKVLSS LSKWLDLPEF
790 800 810 820 830 840
PFETHIRFSP SKGFHCRLIN GKTECLGESK GRKYSEMSQE LRQKLDGIFA LDNSALFKFL
850
RKNRLKIPDW LEEAVRIRV