Q60V73

PR
Gene name
mel-32
Protein name
Serine hydroxymethyltransferase
Names
SHMT, Glycine hydroxymethyltransferase, Maternal effect lethal protein 32, Serine methylase
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
2.1.2.1: Hydroxymethyl-, formyl- and related transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-77 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60V73

Entry ID Method Resolution Chain Position Source
AF-Q60V73-F1 Predicted AlphaFoldDB

No variants for Q60V73

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q60V73

No associated diseases with Q60V73

2 regional properties for Q60V73

Type Name Position InterPro Accession
binding_site Serine hydroxymethyltransferase, pyridoxal phosphate binding site 279 - 295 IPR019798
domain Serine hydroxymethyltransferase-like domain 57 - 454 IPR039429

Functions

Description
EC Number 2.1.2.1 Hydroxymethyl-, formyl- and related transferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

7 GO annotations of molecular function

Name Definition
glycine hydroxymethyltransferase activity Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine.
mRNA 5'-UTR binding Binding to an mRNA molecule at its 5' untranslated region.
mRNA regulatory element binding translation repressor activity Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid.
protein homodimerization activity Binding to an identical protein to form a homodimer.
pyridoxal phosphate binding Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6.
serine binding Binding to 2-amino-3-hydroxypropanoic acid.
zinc ion binding Binding to a zinc ion (Zn).

10 GO annotations of biological process

Name Definition
embryo development ending in birth or egg hatching The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell.
folic acid metabolic process The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines.
glycine biosynthetic process from serine The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine.
L-serine catabolic process The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.
one-carbon metabolic process The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
protein homotetramerization The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits.
purine nucleobase biosynthetic process The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
serine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine.
tetrahydrofolate interconversion The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.
tetrahydrofolate metabolic process The chemical reactions and pathways involving tetrahydrofolate, 5,6,7,8-tetrahydrofolic acid, a folate derivative bearing additional hydrogens on the pterin group.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFARAVSRKT MTGLLAGSRV LLASQFTMAD RQVHTPLEPV QRQKYANNEN LLKDHVEKID
70 80 90 100 110 120
PEVFNIMKNE KSRQRRGLEL IASENFTSKA VMDALGSAMC NKYSEGYPGA RYYGGNEFID
130 140 150 160 170 180
QMEILCQKRA LEVFGLDPAK WGVNVQSLSG SPANFAVYTA LVGANGRIMG LDLPDGGHLT
190 200 210 220 230 240
HGFFTPARKV SATSEFFQSM PYKVDAQSGL IDYDKLEENA MLFRPKVLIA GVSCYARHLD
250 260 270 280 290 300
YERFRKIATK AGAYLMSDMA HISGLVAAGL IPSPFEYSDV VTTTTHKSLR GPRGAMIFYR
310 320 330 340 350 360
KGVRSVNAKG VETLYDLEEK INSAVFPGLQ GGPHNHTIAG IAVALKQCLS EDFVQYGEQI
370 380 390 400 410 420
LKNAKTLAER LKKHGYSLAT GGTDNHLLLV DLRPIGVEGA RAEHILDLAH IACNKNTCPG
430 440 450 460 470 480
DVSALRPGGI RLGTPALTSR GFKEQDFEKV GDFIHEGVQI AKKYNAEAGK TLKDFKAFTA
490 500 510
TNEQFKQEVA ELAKRVEEFS GKFEIPGNDL F