Q60UZ5

PR
Gene name
sur-2 (mdt-23, CBG19759)
Protein name
Mediator of RNA polymerase II transcription subunit 23
Names
Mediator complex subunit 23, Mediator complex subunit sur-2
Species
Caenorhabditis briggsae
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1348-1589 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60UZ5

Entry ID Method Resolution Chain Position Source
AF-Q60UZ5-F1 Predicted AlphaFoldDB

No variants for Q60UZ5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q60UZ5

No associated diseases with Q60UZ5

No regional properties for Q60UZ5

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q60UZ5

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
mediator complex A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.
transcription regulator complex A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

2 GO annotations of biological process

Name Definition
positive regulation of gene expression Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA).
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEKDKAPNP EDVIEMDDSF SPQFVQEVNR VKSQIKSLIE NNTTLRFFKP LTSNLGDVTA
70 80 90 100 110 120
ILRISFNNMM SKMEEKEKQS LVKELIKLVH HVAEKNTQDK VFIAASYERV VDELLRYANQ
130 140 150 160 170 180
KEVISTTLCV EGLIMTSDFR MCSRIDQEKW KFIKECIPKI DYKGIRTIIR YILESQLRRL
190 200 210 220 230 240
PYQLSPEKVN ELRRVEDVLL KIVDRDLNLM PPLITLSEVM RGTPKQAHMF PRLTEKLANL
250 260 270 280 290 300
SSHFRPIADL THVCGRPFIY PIPFHPAFHP PTSYWEDFGM NAQSPYTQSH HMLPYRPQHK
310 320 330 340 350 360
AASCLYTFYM ILRQPLGKDS LNPTNRNKTK SHWEPLLSVM IVEAMAETEA LPEGKQIPRY
370 380 390 400 410 420
QWDNITNLVM YGMSHLLVNP KNFFHYLKGL INQCKYTRAR DEVMWIVFQV VSSLHKMIKI
430 440 450 460 470 480
EDAVQEIVDL YNELFDGEFS WHGASDHPAR MARFLAAAST WMLLEKNKAH KQNTDTIKSH
490 500 510 520 530 540
IKVIHEAALN FDPKNMGMLA VLANAFKSDT RIGAQIVPAM SEALNTPPDP SQPTFDLSYQ
550 560 570 580 590 600
RKAVNQFDAF PKEFLDALTS RAKRSLLGQI LSVFRSFGTD KLPSPAAFET LARICQSEDY
610 620 630 640 650 660
EMAVKDLESL ASRSLHISTQ ERAADIATNN QAKDQCHFLF DFLAYRLPHV HSYGKYTSTT
670 680 690 700 710 720
GSLLLYFTAS VAPNTPQNHQ VYRLLEQALL RRMYWRTFHE SVINHSQLFG SSYKENSNNV
730 740 750 760 770 780
MLRHLKNPKT FSTPVDQWQF PLNPEIFKMT IYAFMRALKI TGQEIPLDGT MHPIHVAGYG
790 800 810 820 830 840
WPEKSTTFFP KWALEEIKKT DVKKLAPNYA EILSTTDEAF RMNTLLTGGQ YVIRYADDPN
850 860 870 880 890 900
PITYHCMLAV IFKQLCSKPE QDLTSEYYQV MEKKSPKDIV VMGNYLVDFI IADVKNNQDC
910 920 930 940 950 960
NEQTFKTIAK TAALMCFHFN IHRADRFLLS LIMHPSTDED AQICIQIANE FLLTPKFQER
970 980 990 1000 1010 1020
IKWFYENDVP RKEKDPYEYI KAIVKYHDAF PEFEACQLVP KNDDTGTNVH MPTYYGCLIE
1030 1040 1050 1060 1070 1080
RLLPILDQYV YVALEQQGYK MSNALLQLVS MFYRYHPMPI HFMYSVLFVS HGKMAGPDAK
1090 1100 1110 1120 1130 1140
SFVSAFASQI EECHLTEEFE KYNHQKSSCE ELIMELLDRM AASLDFVLTP PTFVAKDWRT
1150 1160 1170 1180 1190 1200
AEMSPGAQAL YLACIELMAS PHSPEKLVNA MINVMQMRPH LRPFNVFNLI ALLLTALPST
1210 1220 1230 1240 1250 1260
YADALHEEFI GVFKNGETAN LKFEEIVFDN YDSSLLLHLP NRARSINMIA QIYWTQCNMA
1270 1280 1290 1300 1310 1320
LLNPFANDQV PKLLEHVKTE KDLWYTLRLV MPIIRRFWDS WDFAKTMRAL RERFGPLVIM
1330 1340 1350 1360 1370 1380
KLIIEKLGSM AESGVEIVHE APFCDLFYNC KYVFVGDFLR ETAITEFAKL PEAMRERLKY
1390 1400 1410 1420 1430 1440
YVSQNEPAPP ETPEREKTPE RKDQQKEQQE QQHQQHHQNP QLHHEAQHHP HHPHQQPSMP
1450 1460 1470 1480 1490 1500
PPQLIPQHHL QHHQQQLHHQ QQQQQHLSQM MPPPQQPLQH LPHHQMDMAP PTPAPMHHQQ
1510 1520 1530 1540 1550 1560
HQMAMHQQMY PGQMFHHPQG GHMGYGMQHH MQQPHPHHPQ MQGQMPSQMQ HMVRMHNMTP
1570 1580
QQQQQYAYMM QQQQHHYMQQ QQHQQHHHM