Q60AZ3

PR
Gene name
thrS
Protein name
Threonine--tRNA ligase
Names
Threonyl-tRNA synthetase, ThrRS
Species
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
KEGG Pathway
mca:MCA0693
EC number
6.1.1.3: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

392-462 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60AZ3

Entry ID Method Resolution Chain Position Source
AF-Q60AZ3-F1 Predicted AlphaFoldDB

No variants for Q60AZ3

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q60AZ3

No associated diseases with Q60AZ3

7 regional properties for Q60AZ3

Type Name Position InterPro Accession
domain Aminoacyl-tRNA synthetase, class II (G/ P/ S/T) 321 - 528 IPR002314
domain TGS 1 - 61 IPR004095
domain Anticodon-binding 540 - 629 IPR004154
domain Aminoacyl-tRNA synthetase, class II 242 - 533 IPR006195
domain Threonyl/alanyl tRNA synthetase, SAD 169 - 218 IPR012947
domain Threonine-tRNA ligase catalytic core domain 241 - 538 IPR033728
domain Threonine-tRNA ligase, class IIa, anticodon-binding domain 538 - 627 IPR047246

Functions

Description
EC Number 6.1.1.3 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
threonine-tRNA ligase activity Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
threonyl-tRNA aminoacylation The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPVVTLPDGS RREFDHPVTL LQVAEAIGPG LAKAALAGRV DGRLVDLSHR IEADAEVALV
70 80 90 100 110 120
TARDADGVEV IRHSTAHLLA QAVKALYPKA QVTIGPVIQD GFYYDFSYER PFTPEDLEAI
130 140 150 160 170 180
EAKMHELAAQ ALPVERRTMP REEAIAYFRS LGEAYKAEII EAIPRGEVIS LYSQGDFTDL
190 200 210 220 230 240
CRGPHVPDTG RLNAFKLMKI AGAYWRGDSR NEMLQRIYGT AWGDRKDLAA YLQRLEEAER
250 260 270 280 290 300
RDHRKLGKAL DLFHMQEEAP GMVFWHPKGW ILWQEIEQYM RRVFRDNGYQ EIRTPLVVAR
310 320 330 340 350 360
TLWERSGHWE KFSDEMFTTA SEERDYAIKP MNCPCHVQVY NQGLKSYRDL PLRLAEFGSC
370 380 390 400 410 420
HRNELSGALH GLMRVRGFTQ DDAHIFCTEE QIQDEVSRFI DLLFKVYADF GFSEVQIKLS
430 440 450 460 470 480
TRPEKRVGSD EVWDKAEHAL ETALNAKGLA WDLQPGEGAF YGPKIEFSLK DCLDRVWQCG
490 500 510 520 530 540
TIQVDFSMPD RLGATYVAED GARHVPVMLH RAILGSLERF VGILTEHYAG QYPLWLAPVQ
550 560 570 580 590 600
AVVLNITDRQ ADYAREVAQE FVSKGFRVIA DLRNEKVGFK IREHSMQRVP YLLIVGDKEV
610 620 630
EAGSVSLRTR DGKDHGSFGI GDLVAKFTEE TMKRAVSH