Q60936

SS
Gene name
Coq8a
Protein name
Atypical kinase COQ8A, mitochondrial
Names
Chaperone activity of bc1 complex-like, Chaperone-ABC1-like, Coenzyme Q protein 8A, aarF domain-containing protein kinase 3
Species
Mus musculus (Mouse)
KEGG Pathway
mmu:67426
EC number
Protein Class

Descriptions

UbiB protein kinase-like (PKL) family is wide-spread, comprising one-quarter of microbial PKLs and five human homologs. Coq8a is a mammalian UbiB protein associated with ubiquinone (CoQ) biosynthesis. A human homolog (COQ8A) lacks canonical protein kinase activity in trans. Instead, it has ATPase activity and interacts with lipid CoQ intermediates. Autoinhibition is achieved by the N-terminal region containing KxGQ motif, which occludes the substrate binding site of the kinase domain within the same polypeptide.

Autoinhibitory domains (AIDs)

273-276 (KxGQ motif) SS

Target domain

292-542 (ADCK3-like domain)

Relief mechanism

PTM

Assay

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60936

Entry ID Method Resolution Chain Position Source
AF-Q60936-F1 Predicted AlphaFoldDB

8 variants for Q60936

Variant ID(s) Position Change Description Diseaes Association Provenance
rs233662836 51 F>I No Ensembl
rs230562844 56 G>R No Ensembl
rs32573072 103 S>A No Ensembl
rs226922192 104 L>P No Ensembl
rs32686560 159 S>F No Ensembl
rs237777297 166 S>P No Ensembl
rs864273141 474 R>* No Ensembl
rs32681538 643 G>A No Ensembl

No associated diseases with Q60936

7 regional properties for Q60936

Type Name Position InterPro Accession
conserved_site ATP-dependent RNA helicase DEAD-box, conserved site 246 - 254 IPR000629
domain Helicase, C-terminal 327 - 475 IPR001650
domain DEAD/DEAH box helicase domain 118 - 288 IPR011545
repeat RNA helicase p68 repeat 498 - 532 IPR012587-1
repeat RNA helicase p68 repeat 551 - 583 IPR012587-2
domain Helicase superfamily 1/2, ATP-binding domain 113 - 316 IPR014001
domain RNA helicase, DEAD-box type, Q motif 94 - 122 IPR014014

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Membrane ; Single-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
extrinsic component of mitochondrial inner membrane The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ADP binding Binding to ADP, adenosine 5'-diphosphate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
kinase activity Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.

2 GO annotations of biological process

Name Definition
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
ubiquinone biosynthetic process The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme.

11 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P27697 COQ8 Atypical kinase COQ8, mitochondrial Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) SS
Q29RI0 COQ8A Atypical kinase COQ8A, mitochondrial Bos taurus (Bovine) SS
Q96D53 COQ8B Atypical kinase COQ8B, mitochondrial Homo sapiens (Human) SS
Q8NI60 COQ8A Atypical kinase COQ8A, mitochondrial Homo sapiens (Human) EV
Q566J8 Coq8b Atypical kinase COQ8B, mitochondrial Mus musculus (Mouse) SS
Q6AY19 Coq8b Atypical kinase COQ8B, mitochondrial Rattus norvegicus (Rat) SS
Q5BJQ0 Coq8a Atypical kinase COQ8A, mitochondrial Rattus norvegicus (Rat) SS
Q18486 coq-8 Atypical kinase coq-8, mitochondrial Caenorhabditis elegans SS
Q9SBB2 ABC1 Protein ABC transporter 1, mitochondrial Arabidopsis thaliana (Mouse-ear cress) SS
A3QJU3 coq8b Atypical kinase COQ8B, mitochondrial Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q5RGU1 coq8a Atypical kinase COQ8A, mitochondrial Danio rerio (Zebrafish) (Brachydanio rerio) SS
10 20 30 40 50 60
MAAMLGDAIM VAKGLAKLTQ AAVETHLQNL GLGGELLLAA RALQSTAVEQ FSMVFGKVQG
70 80 90 100 110 120
QDKHEDSYAT ENFEDLEAEV QFSTPQAAGT SLDFSAASSL DQSLSPSHSQ GPAPAYASSG
130 140 150 160 170 180
PFREAGLPGQ ATSPMGRVNG RLFVDHRDLF LANGIQRRSF HQDQSSVGGL TAEDIEKARQ
190 200 210 220 230 240
AKARPESKPH KQMLSERARE RKVPVTRIGR LANFGGLAVG LGIGALAEVA KKSLRSENST
250 260 270 280 290 300
GKKAVLDSSP FLSEANAERI VSTLCKVRGA ALKLGQMLSI QDDAFINPHL AKIFERVRQS
310 320 330 340 350 360
ADFMPLKQMT KTLNSDLGPH WRDKLEYFEE RPFAAASIGQ VHLARMKGGR EVAMKIQYPG
370 380 390 400 410 420
VAQSINSDVN NLMAVLNMSN MLPEGLFPEH LIDVLRRELT LECDYQREAA YAKKFRELLK
430 440 450 460 470 480
DHPFFYVPEI VDELCSPHVL TTELISGFPL DQAEGLSQEV RNEICYNILV LCLRELFEFH
490 500 510 520 530 540
VMQTDPNWSN FFYDPQQHKV ALLDFGATRE YDRSFTDLYI QVIRAAADQD REAVLKKSIE
550 560 570 580 590 600
MKFLTGYEVK AMEDAHLDAI LILGEAFASE EPFDFGTQST TEKIHNLIPV MLKHRLIPPP
610 620 630 640
EETYSLHRKM GGSFLICSKL KARFPCKAMF EEAYSNYCRM KSGLQ