Q60437

PR
Gene name
BAIAP2
Protein name
Brain-specific angiogenesis inhibitor 1-associated protein 2
Names
BAI-associated protein 2, BAI1-associated protein 2, Insulin receptor substrate protein of 53 kDa, IRSp53, Insulin receptor substrate p53, Insulin receptor tyrosine kinase 53 kDa substrate, p58/p53
Species
Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

285-380 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60437

Entry ID Method Resolution Chain Position Source
AF-Q60437-F1 Predicted AlphaFoldDB

No variants for Q60437

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q60437

No associated diseases with Q60437

4 regional properties for Q60437

Type Name Position InterPro Accession
domain SH3 domain 375 - 438 IPR001452
domain IMD/I-BAR domain 1 - 250 IPR013606
domain I-BAR domain containing protein IRSp53, Inverse-Bin/Amphiphysin/Rvs domain 5 - 236 IPR030128
domain IRSp53, SH3 domain 378 - 436 IPR035594

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Membrane ; Peripheral membrane protein
  • Cell projection, filopodium
  • Cell projection, ruffle
  • Cytoplasm, cytoskeleton
  • Detected throughout the cytoplasm in the absence of specific binding partners
  • Detected in filopodia and close to membrane ruffles
  • Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites (By similarity)
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cytoskeleton A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
filopodium Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
ruffle Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork.

2 GO annotations of molecular function

Name Definition
cytoskeletal anchor activity The binding activity of a protein that brings together a cytoskeletal protein (either a microtubule or actin filament, spindle pole body, or protein directly bound to them) and one or more other molecules, permitting them to function in a coordinated way.
proline-rich region binding Binding to a proline-rich region, i.e. a region that contains a high proportion of proline residues, in a protein.

6 GO annotations of biological process

Name Definition
actin crosslink formation The process in which two or more actin filaments are connected together by proteins that act as crosslinks between the filaments. The crosslinked filaments may be on the same or differing axes.
actin filament bundle assembly The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.
plasma membrane organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane.
regulation of actin cytoskeleton organization Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
regulation of cell shape Any process that modulates the surface configuration of a cell.
response to bacterium Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLSRSEEMH RLTENVYKTI MEQFNPSLRN FIAMGKNYEK ALAGVTFAAK GYFDALVKMG
70 80 90 100 110 120
ELASESQGSK ELGDVLFQMA EVHRQIQNQL EEMLKSFHNE LLTQLEQKVE LDSRYLSAAL
130 140 150 160 170 180
KKYQAEQRSK GDALDKCQAE LKKLRKKSQG SKNPQKYSDK ELQYIDAISN KQGELENYVS
190 200 210 220 230 240
DGYKTALTEE RRRFCFLVEK QCAVAKNSAA YHSKGKELLA QKLPVWQQAC ADPNKIPDRA
250 260 270 280 290 300
VQLMQQIASS NGSILPSTLS ASKSNLVISD PIPGAKPLPV PPELAPFVGR MSAQENVPVM
310 320 330 340 350 360
NGVAGPDSED YNPWADRKAA QPKSLSPPQS QSKLSDSYSN TLPVRKSVTP KNSYATTENK
370 380 390 400 410 420
TLPRSSSMAA GLERNGRMRV KAIFSHAAGD NSTLLSFKEG DLITLLVPEA RDGWHYGESE
430 440 450 460 470 480
KTKMRGWFPF SYTRVLDSDG SDRLHMSLQQ GKSSSTGNLL DKDDLAVPPP DYGTSSRAFP
490 500 510 520
TQTAGTFKQR PYSVAVPAFS QGLDDYGARS VSSADVEVAR F