Q60182
Gene name |
glnA |
Protein name |
Glutamine synthetase |
Names |
GS, Glutamate--ammonia ligase, Glutamine synthetase I alpha, GSI alpha |
Species |
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) |
KEGG Pathway |
mja:MJ_1346 |
EC number |
6.3.1.2: Acid--ammonia (or amine) ligases (amide synthases) |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q60182
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q60182-F1 | Predicted | AlphaFoldDB |
No variants for Q60182
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q60182 | |||||
No associated diseases with Q60182
4 regional properties for Q60182
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Glutamine synthetase, catalytic domain | 115 - 454 | IPR008146 |
| domain | Glutamine synthetase, N-terminal domain | 19 - 111 | IPR008147 |
| conserved_site | Glutamine synthetase, N-terminal conserved site | 62 - 80 | IPR027302 |
| conserved_site | Glutamine synthetase, glycine-rich site | 244 - 259 | IPR027303 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.3.1.2 | Acid--ammonia (or amine) ligases (amide synthases) |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| glutamate-ammonia ligase activity | Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate. |
| metal ion binding | Binding to a metal ion. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| glutamine biosynthetic process | The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHWGMEMNVE | QAIEYVKKNN | VKFIRFQFVD | ILGFPKNVAY | PVKAGEKGIE | ELREIFENGV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| WFDGSSITGF | VGIEESDMLL | KPDLSTLSVL | PWRPEEKSVA | RVICDVYKDE | KTPFEGDPRS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| RLKAILEELK | KEMNGEYFVG | PEPEFFLLKR | DPHNPHRWVP | ADDGGYFDVE | PLDDAPDIRR |
| 190 | 200 | 210 | 220 | 230 | 240 |
| DIVLALENLG | FHVEASHHEV | APGQHEVDFK | FDNALKTADS | VITFKMTIKN | IAKKHGLKAT |
| 250 | 260 | 270 | 280 | 290 | 300 |
| FMPKPFFGMN | GNGMHCHQSV | WFNGEPSFYD | PEGPYNGLSE | TCLSYIAGIL | SHAKALVAIT |
| 310 | 320 | 330 | 340 | 350 | 360 |
| NPTVNSYKRL | VPGYEAPVNI | AWANKNRSAI | IRVPAARGKA | TRIEFRAPDP | TCNPYLAFAC |
| 370 | 380 | 390 | 400 | 410 | 420 |
| MLAAGLDGIK | KKMTAPEPVE | RNIFKMSEEE | KKQLGIESVP | ANLAAALDEL | ECDEVLQKAL |
| 430 | 440 | 450 | |||
| GKHIYENYME | IKRAEWDDFR | TAVTDWETGK | YLIY |