Q60181

PR
Gene name
rpo2C
Protein name
DNA-directed RNA polymerase subunit Rpo2C
Names
DNA-directed RNA polymerase subunit B'
Species
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
KEGG Pathway
mja:MJ_1041
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

3-76 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q60181

Entry ID Method Resolution Chain Position Source
AF-Q60181-F1 Predicted AlphaFoldDB

No variants for Q60181

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q60181

No associated diseases with Q60181

5 regional properties for Q60181

Type Name Position InterPro Accession
domain DNA-directed RNA polymerase, subunit 2, hybrid-binding domain 137 - 507 IPR007120
conserved_site RNA polymerase, beta subunit, conserved site 360 - 372 IPR007121
domain RNA polymerase Rpb2, domain 7 509 - 599 IPR007641
domain RNA polymerase Rpb2, domain 4 6 - 67 IPR007646
domain RNA polymerase Rpb2, domain 5 89 - 120 IPR007647

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKNLASREVN IYVNGKLVGT TDKPEELVNF IREKRRKGEL PQYTTVAYNE ESNDIHINTD
70 80 90 100 110 120
AGRIVRPLIV VENGKPKLTK EHIEKLKKGE ITFSDLVKEG VIEYLDAEEE ENAYIALSEE
130 140 150 160 170 180
ELTEKHTHLE IDPLTILGIG AGVAPYPEHN SAPRITMAAA MGKQSLGIPM SNIKWRLDTR
190 200 210 220 230 240
GHYLHYPQVP IVRTKHQEIL GFDKRPAGQN FVVAIMSYEG YNMEDAIVFN KSAIDRGLGR
250 260 270 280 290 300
STFFRTYDAC ERRYPGGQMD RFEIPDKGVR GYRSEECYRY LEEDGIVAVE SHVKGGDVIV
310 320 330 340 350 360
GKTSPPRFLE EHEITIQVKP QRRDSSVVVR HGEEGYIDKV ILTETKEGNR LVKVKVRDLR
370 380 390 400 410 420
IPELGDKFAS RHGQKGVMGL TVPQEDLPFT ESGIVPDIII NPHAIPSRMT VGQLLEMLGG
430 440 450 460 470 480
KVGALEGRRI DGTIFSGEKE WDLRKALEAL GFKHHGKEVM YDGKTGKKFE VEIYIGIAYY
490 500 510 520 530 540
QKLHHLVAGK IHARSRGPVQ VLTRQPTEGR AREGGLRFGE MERDVLIGHG AAMLLKERLM
550 560 570 580 590 600
DESDPYDICI CSKCGDFAIL DYKRGLKYCP ICGEIENLYS SKKIPFVRIP YAFKLLLDEL
610 620 630
KSMCILPRIK VRDKVELEDF EEFVEKLEKE KVKQKQ