Q60048

PR
Gene name
cadA
Protein name
Probable cadmium-transporting ATPase
Names
Cadmium-efflux ATPase
Species
Listeria monocytogenes
KEGG Pathway
EC number
7.2.2.21: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

29-106 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for Q60048

Entry ID Method Resolution Chain Position Source
2AJ0 NMR - A 1-71 PDB
2AJ1 NMR - A 1-71 PDB
AF-Q60048-F1 Predicted AlphaFoldDB

No variants for Q60048

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q60048

No associated diseases with Q60048

4 regional properties for Q60048

Type Name Position InterPro Accession
domain Heavy metal-associated domain, HMA 3 - 66 IPR006121
conserved_site Heavy-metal-associated, conserved site 9 - 38 IPR017969
ptm P-type ATPase, phosphorylation site 398 - 404 IPR018303
domain P-type ATPase, haloacid dehalogenase domain 378 - 656 IPR044492

Functions

Description
EC Number 7.2.2.21 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
metal ion binding Binding to a metal ion.
P-type cadmium transporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out).

1 GO annotations of biological process

Name Definition
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAEKTVYRVD GLSCTNCAAK FERNVKEIEG VTEAIVNFGA SKITVTGEAS IQQVEQAGAF
70 80 90 100 110 120
EHLKIIPEKE SFTDPEHFTD HQSFIRKNWR LLLSGLFIAV GYASQIMNGE DFYLTNALFI
130 140 150 160 170 180
FAIFIGGYSL FKEGFKNLLK FEFTMETLMT IAIIGAAFIG EWAEGSIVVI LFAVSEALER
190 200 210 220 230 240
YSMDKARQSI RSLMDIAPKE ALVRRSGTDR MVHVDDIQIG DIMIIKPGQK IAMDGHVVKG
250 260 270 280 290 300
YSAVNQAAIT GESIPVEKNI DDSVFAGTLN EEGLLEVAVT KRVEDTTISK IIHLVEEAQG
310 320 330 340 350 360
ERAPAQAFVD TFAKYYTPAI IVIAALIATV PPLLFGGNWE TWVYQGLSVL VVGCPCALVV
370 380 390 400 410 420
STPVAIVTAI GNAAKNGVLV KGGVYLEEIG GLKAIAFDKT GTLTKGVPVV TDYIELTEAT
430 440 450 460 470 480
NIQHNKNYII MAALEQLSQH PLASAIIKYG ETREMDLTSI NVNDFTSITG KGIRGTVDGN
490 500 510 520 530 540
TYYVGSPVLF KELLASQFTD SIHRQVSDLQ LKGKTAMLFG TNQKLISIVA VADEVRSSSQ
550 560 570 580 590 600
HVIKRLHELG IEKTIMLTGD NQATAQAIGQ QVGVSEIEGE LMPQDKLDYI KQLKINFGKV
610 620 630 640 650 660
AMVGDGINDA PALAAATVGI AMGGAGTDTA IETADVALMG DDLQKLPFTV KLSRKTLQII
670 680 690 700 710
KQNITFSLVI KLIALLLVIP GWLTLWIAIM ADMGATLLVT LNGLRLMKVK D