Q5ZVH7

PR
Gene name
secA
Protein name
Protein translocase subunit SecA
Names
Species
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
KEGG Pathway
lpn:lpg1463
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

814-892 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZVH7

Entry ID Method Resolution Chain Position Source
AF-Q5ZVH7-F1 Predicted AlphaFoldDB

No variants for Q5ZVH7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZVH7

No associated diseases with Q5ZVH7

9 regional properties for Q5ZVH7

Type Name Position InterPro Accession
domain Helicase, C-terminal 429 - 631 IPR001650
conserved_site SEC-C motif 876 - 893 IPR004027
domain SecA DEAD-like, N-terminal 6 - 397 IPR011115
domain SecA Wing/Scaffold 613 - 825 IPR011116
domain SecA, preprotein cross-linking domain 228 - 353 IPR011130
domain Helicase superfamily 1/2, ATP-binding domain 89 - 247 IPR014001
domain SecA motor DEAD 3 - 615 IPR014018
conserved_site SecA conserved site 495 - 510 IPR020937
domain SecA, C-terminal helicase domain 415 - 585 IPR044722

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Cytoplasm
  • Distribution is 50-50
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

3 GO annotations of biological process

Name Definition
intracellular protein transmembrane transport The directed movement of proteins in a cell, from one side of a membrane to another by means of some agent such as a transporter or pore.
protein import The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event.
protein targeting The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MLSTLIKKMF GSRNERTLRR MEKSVMAINA FEPKMQALSN EELAGKTQEF KERFNNGESL
70 80 90 100 110 120
DELLAEAFAT VREVSLRTLG LRHFDVQLIG GMVLHEGNIA EMRTGEGKTL VATLPAYLNA
130 140 150 160 170 180
ISGRGVHIVT VNDYLAKRDS QWMKPIYEFL GLTVGVIYPD MSHKEKQEAY KADIVYGTNN
190 200 210 220 230 240
EYGFDYLRDN MAFSLTDKVQ RELNFAIVDE VDSILIDEAR TPLIISGAAE DSSELYIKIN
250 260 270 280 290 300
SLIPQLKKQE EEGDEGDYTI DEKQKQAHLT DAGHLHIEEL LTKAKLLDPG ESLYHASNIM
310 320 330 340 350 360
LMHHVNAALK AHAMFHRDID YIVKDNQVVI VDEHTGRTMP GRRWSEGLHQ AVEAKEGVPI
370 380 390 400 410 420
QNENQTLASI TFQNFFRMYN KLSGMTGTAD TEAYEFQQIY NLEVVVIPTN RSMIRKDEAD
430 440 450 460 470 480
LVYLTQADKF QAIIEDVREC GVRRQPVLVG TVSIEASEFL SQLLKKENIK HQVLNAKFHE
490 500 510 520 530 540
KEAQIIAEAG RPGAVTIATN MAGRGTDIVL GGSLAADLAN LPADASEQEK EAVKKEWQKR
550 560 570 580 590 600
HDEVIAAGGL RIIGSERHES RRIDNQLRGR AGRQGDPGSS RFYLSLEDNL MRIFASERVA
610 620 630 640 650 660
SMMRRLGMQP GEPIEHSLVT RAIENAQRKL EGHHFDVRKQ LLDYDNVAND QRQVIYTQRS
670 680 690 700 710 720
SIMAMTDTQE VVEMMREEVM DSLVDTYIPP QSLEDQWDPQ ALSDVLSDEF KIKAPVPDWI
730 740 750 760 770 780
DKDHSIQPEK IKEKILALAI EHYDEKVRKV GRPVISQFEK SIILQTLDNH WREHLAAMDQ
790 800 810 820 830 840
LRQGIHLRGY AQKDPKQEYK KEAFSLFTMM LDNLKYEVIR ILSSVEIQTE EDAHVVEEQR
850 860 870 880 890
RADQIRKMNL MHESLSENDE ASETQTFRRQ EKKIGRNDPC PCGSGKKYKA CHGSLV