Q5ZU30

PR
Gene name
setA (lpg1978)
Protein name
Subversion of eukaryotic traffic protein A
Names
Effector protein SetA, Subversion of eukaryotic vesicle trafficking A
Species
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
KEGG Pathway
lpn:lpg1978
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

454-551 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for Q5ZU30

Entry ID Method Resolution Chain Position Source
7TOD NMR - A 522-629 PDB
AF-Q5ZU30-F1 Predicted AlphaFoldDB

No variants for Q5ZU30

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZU30

No associated diseases with Q5ZU30

1 regional properties for Q5ZU30

Type Name Position InterPro Accession
conserved_site Glycosyltransferase, DXD sugar-binding motif 42 - 147 IPR007577

Functions

Description
EC Number
Subcellular Localization
  • Secreted
  • Is secreted by the Dot/Icm type IV secretion system (T4SS) into the host cell cytosol
  • Localizes to vesicular compartments in mammalian cells, more precisely to early endosomes and early Legionella-containing phagosomes
  • After translocation by the Dot/Icm system, a portion of SetA associates with host cell membranes while another portion of SetA remains in the host cell cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
extracellular region The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.

1 GO annotations of molecular function

Name Definition
glycosyltransferase activity Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).

No GO annotations of biological process

Name Definition
No GO annotations for biological process

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MYKIYSYLGW RIDMKTENLP QAGQEAQIDK KIHFIWVGHI MPQKNIQVVS EWAEKNPGYE
70 80 90 100 110 120
TIIWVDKKIA PAKELDLFIL DMKSKGITVK DINEEGVCRD SIRHELDQES PNYGMVSDML
130 140 150 160 170 180
RLNILAAEGG IYLDSDILCS APFPDEIYAP FGFLLSPWSQ GANNTLCNDI ILCSKGNQII
190 200 210 220 230 240
QQLADAIEQS YIARDSFEFT HEYASMKETK GERIAKTLGV TGPGFLFHQL KKMGILNDKS
250 260 270 280 290 300
EMEAIHWELQ DQRYLIDGSV KEPDYFYVPQ NNTNDASWVP SIKRPGIENM SFQERLENAV
310 320 330 340 350 360
QLIAFDIQKT GLFNLDHYAN ELKVKQNSWC IAAETSPELK PDSYLLIRPR DKTGEWTLYY
370 380 390 400 410 420
VDEDKKLNPV TLPVIKGAIK LSEVSDPLRK FHTLLSQVSD PVNPTAHELK QIGRALIELK
430 440 450 460 470 480
PRQDEWHCKN KWSGAEEIAQ ELWQRITSNE TLRAQIKQCF TQFESLKPRV AELGLTRASG
490 500 510 520 530 540
AGTEVEAHES TVKEQEIISQ NTVGEEGTKE KNSVQLASEN SSDEKIKTAH DLIDEIIQDV
550 560 570 580 590 600
IQLDGKLGLL GGNTRQLEDG RVINIPNGAA MIFDDYKKYK QGELTAESAL ESMIKIAKLS
610 620 630 640
NQLNRHTFFN QRQPETGQFY KKVAAIDLQT TIAAEYDNNH GLRI