Q5ZMJ4

PR
Gene name
GK5 (RCJMB04_1n17)
Protein name
Putative glycerol kinase 5
Names
GK 5, Glycerokinase 5, ATP:glycerol 3-phosphotransferase 5
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:424779
EC number
2.7.1.30: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

419-517 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZMJ4

Entry ID Method Resolution Chain Position Source
AF-Q5ZMJ4-F1 Predicted AlphaFoldDB

11 variants for Q5ZMJ4

Variant ID(s) Position Change Description Diseaes Association Provenance
rs1058944300 49 Y>C No Ensembl
rs1060192994 121 L>P No Ensembl
rs794497550 223 K>R No Ensembl
rs794180671 231 H>N No Ensembl
rs740249391 268 V>G No Ensembl
rs738265804 270 D>G No Ensembl
rs793896457 377 N>D No Ensembl
rs741774262 476 T>A No Ensembl
rs732081004 486 Q>R No Ensembl
rs738274762 487 I>V No Ensembl
rs314490072 498 K>E No Ensembl

No associated diseases with Q5ZMJ4

3 regional properties for Q5ZMJ4

Type Name Position InterPro Accession
conserved_site Carbohydrate kinase, FGGY, conserved site 383 - 403 IPR018483
domain Carbohydrate kinase, FGGY, N-terminal 15 - 277 IPR018484
domain Carbohydrate kinase, FGGY, C-terminal 287 - 471 IPR018485

Functions

Description
EC Number 2.7.1.30 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glycerol kinase activity Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+).
phosphotransferase activity, alcohol group as acceptor Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor).

5 GO annotations of biological process

Name Definition
glycerol catabolic process The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
glycerol metabolic process The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids.
glycerol-3-phosphate biosynthetic process The chemical reactions and pathways resulting in the formation of glycerol-3-phosphate, a phosphoric monoester of glycerol.
phosphorylation The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide.
triglyceride metabolic process The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPCGQPGSGA APALYVVGVD VGSTTVKCHV YDRAAGVRGS SCRKVESLYP RPGWVELDPE
70 80 90 100 110 120
VLWSQFVGVI KEAVQAAGLH MRQVAALGIS TQRSTFITWH KRTGKPFHNF ISWQDLRSAE
130 140 150 160 170 180
LVNSWNRSLL LKVIHVIFTV LHFFTGNDRY LAPSVLTFST QQTSMKLSWV FKNIPEADEA
190 200 210 220 230 240
AKKNNCCFGT VDTWLLYRLT KGSVFATDYS NASSTGVFEP FTKCWNPTLC HLLSIPMSIY
250 260 270 280 290 300
PPVKDTSFNF GSADSEIFGV PVPIMALVAD QQSAMFGECC FQPGDVKLTM GTGGFWNVNT
310 320 330 340 350 360
GGNLFASHKG LYPLIGWKIG EEVVYLTEGS MSNIGTTIKW AQDINLFTNV DETAKMARSI
370 380 390 400 410 420
VDSQGVCFVP GFQVSANDPY LCASFMGLKP TTTRNHLVRA ILESVAFRNK QLFDIIVKKV
430 440 450 460 470 480
RIPLQTVRAD GGVSNNSFVM QMTSDLINKK IEKPSNTDMS SLGAAFLAGL ASGLWTDKEQ
490 500 510
LKKLRQIETV FEPQKDEKEY KPAMDTWMRA VKCSLHW