Q5ZLL1

SS
Gene name
CSNK1E (DBT, RCJMB04_5k10)
Protein name
Casein kinase I isoform epsilon
Names
CKI-epsilon, CKIe
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:378891
EC number
2.7.11.1: Protein-serine/threonine kinases
Protein Class

Descriptions

Casein kinase I epsilon (CSNK1E) is a member of CKI family and is involved in signaling, circadian clock, DNA repair, and metabolism. The tail of autophosphorylated CKI琯 interacts with the kinase domain to block the active site. Proteolytic lysis of C-terminal region relieves autoinhibition.

Autoinhibitory domains (AIDs)

293-416 (C-terminal domain) SS

Target domain

9-287 (Protein kinase domain)

Relief mechanism

Cleavage, PTM

Assay

Accessory elements

148-178 (Activation loop from InterPro)

Target domain

9-287 (Protein kinase domain)

Relief mechanism

Assay

References

Autoinhibited structure

Activated structure

1 structures for Q5ZLL1

Entry ID Method Resolution Chain Position Source
AF-Q5ZLL1-F1 Predicted AlphaFoldDB

20 variants for Q5ZLL1

Variant ID(s) Position Change Description Diseaes Association Provenance
rs731981947 19 S>A No Ensembl
rs1057670624 115 R>C No Ensembl
rs731136982 146 Y>S No Ensembl
rs734039002 199 L>P No Ensembl
rs731228179 208 L>R No Ensembl
rs734626304 214 Q>R No Ensembl
rs732534269 278 H>P No Ensembl
rs736609621 313 R>G No Ensembl
rs733194740 317 M>R No Ensembl
rs737143942 320 L>P No Ensembl
rs732384450 323 S>P No Ensembl
rs1057709677 345 A>T No Ensembl
rs732142556 350 S>P No Ensembl
rs738252137 351 T>P No Ensembl
rs740291517 353 T>P No Ensembl
rs731369259 354 S>P No Ensembl
rs736434515 376 V>G No Ensembl
rs733027077 390 S>P No Ensembl
rs1058937456 392 D>N No Ensembl
rs733637832 396 R>G No Ensembl

No associated diseases with Q5ZLL1

3 regional properties for Q5ZLL1

Type Name Position InterPro Accession
domain Protein kinase domain 9 - 287 IPR000719
active_site Serine/threonine-protein kinase, active site 124 - 136 IPR008271
binding_site Protein kinase, ATP binding site 15 - 38 IPR017441

Functions

Description
EC Number 2.7.11.1 Protein-serine/threonine kinases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
ribonucleoprotein complex A macromolecular complex that contains both RNA and protein molecules.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.
protein serine/threonine/tyrosine kinase activity Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate.

11 GO annotations of biological process

Name Definition
circadian regulation of gene expression Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.
endocytosis A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle.
negative regulation of Wnt signaling pathway Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway.
peptidyl-serine phosphorylation The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine.
positive regulation of canonical Wnt signaling pathway Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
positive regulation of non-canonical Wnt signaling pathway Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway.
positive regulation of proteasomal ubiquitin-dependent protein catabolic process Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
protein phosphorylation The process of introducing a phosphate group on to a protein.
regulation of circadian rhythm Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours.
regulation of protein localization Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.
Wnt signaling pathway The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state.

15 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P29295 HRR25 Casein kinase I homolog HRR25 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P35508 CSNK1D Casein kinase I isoform delta Bos taurus (Bovine) SS
P48730 CSNK1D Casein kinase I isoform delta Homo sapiens (Human) SS
Q86Y07 VRK2 Serine/threonine-protein kinase VRK2 Homo sapiens (Human) PR
P49674 CSNK1E Casein kinase I isoform epsilon Homo sapiens (Human) EV
Q9DC28 Csnk1d Casein kinase I isoform delta Mus musculus (Mouse) PR
Q8BN21 Vrk2 Serine/threonine-protein kinase VRK2 Mus musculus (Mouse) PR
Q9JMK2 Csnk1e Casein kinase I isoform epsilon Mus musculus (Mouse) SS
Q06486 Csnk1d Casein kinase I isoform delta Rattus norvegicus (Rat) PR
P42169 C03C10.2 Putative casein kinase I C03C10.2 Caenorhabditis elegans PR
P34516 K06H7.8 Putative serine/threonine-protein kinase K06H7.1 Caenorhabditis elegans PR
Q6P647 csnk1d Casein kinase I isoform delta Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) SS
Q7T2E3 csnk1da Casein kinase I isoform delta-A Danio rerio (Zebrafish) (Brachydanio rerio) PR
Q6P3K7 csnk1db Casein kinase I isoform delta-B Danio rerio (Zebrafish) (Brachydanio rerio) SS
Q7ZUS1 vrk1 Serine/threonine-protein kinase VRK1 Danio rerio (Zebrafish) (Brachydanio rerio) PR
10 20 30 40 50 60
MELRVGNKYR LGRKIGSGSF GDIYLGANIA TGEEVAIKLE CVKTKHPQLH IESKFYKMMQ
70 80 90 100 110 120
GGVGIPSIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF SLKTVLLLAD QMISRIEYIH
130 140 150 160 170 180
SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF GLAKKYRDAR THQHIPYREN KNLTGTARYA
190 200 210 220 230 240
SINTHLGIEQ SRRDDLESLG YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL
250 260 270 280 290 300
CKGYPSEFST YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGAARN
310 320 330 340 350 360
PEDMDRERRE HEREERMGQL RGSATRALPP GPPAGATGNR LRNVAEPMAS TPTSRIQQSG
370 380 390 400 410
NTSPRAISRV DRERKVSMRL HRGAPANVSS SDLTGRQEVS RISASQTSVP FDHLGK