Q5ZJU3

PR
Gene name
ASNS (RCJMB04_15l3)
Protein name
Asparagine synthetase [glutamine-hydrolyzing]
Names
Glutamine-dependent asparagine synthetase
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:420574
EC number
6.3.5.4: Carbon--nitrogen ligases with glutamine as amido-N-donor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

466-561 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZJU3

Entry ID Method Resolution Chain Position Source
AF-Q5ZJU3-F1 Predicted AlphaFoldDB

7 variants for Q5ZJU3

Variant ID(s) Position Change Description Diseaes Association Provenance
rs312748911 47 F>S No Ensembl
rs730889010 48 H>P No Ensembl
rs737830635 64 V>G No Ensembl
rs741548800 99 E>G No Ensembl
rs10724145 103 H>Y No Ensembl
rs10727702 197 V>A No Ensembl
rs314516960 542 V>G No Ensembl

No associated diseases with Q5ZJU3

3 regional properties for Q5ZJU3

Type Name Position InterPro Accession
conserved_site Clathrin adaptor, mu subunit, conserved site 157 - 177 IPR018240-1
conserved_site Clathrin adaptor, mu subunit, conserved site 253 - 267 IPR018240-2
domain Mu homology domain 157 - 421 IPR028565

Functions

Description
EC Number 6.3.5.4 Carbon--nitrogen ligases with glutamine as amido-N-donor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
asparagine synthase (glutamine-hydrolyzing) activity Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.

6 GO annotations of biological process

Name Definition
asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid.
cellular response to glucose starvation Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.
L-asparagine biosynthetic process The chemical reactions and pathways resulting in the formation of asparagine, (2S)-2-amino-3-carbamoylpropanoic acid.
negative regulation of apoptotic process Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process.
positive regulation of mitotic cell cycle Any process that activates or increases the rate or extent of progression through the mitotic cell cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MCGIWALFGS DECLSVQCLS AMKIAHRGPD AFRFENVNGF TNCCFGFHRL AVVDQLYGMQ
70 80 90 100 110 120
PIRVKKFPYL WLCYNGEIYN FKQLQEQFGF EYQTLVDGEV ILHLYNRGGI EQTASMLDGV
130 140 150 160 170 180
FAFILLDTAN RKVFLARDTY GVRPLFKVLT DDGFLGVCSE AKGLINLKHS TSLFPKVEPF
190 200 210 220 230 240
LPGHYEVLDL KPSGKVVSVE VVKFHSYKDE PLHAACDTVG NLPSGFDLET VKSNIRVLFE
250 260 270 280 290 300
NAVRKRLMAH RRIGCLLSGG LDSSLVAAVL LKLMKEMNIK YPLQTFAIGM ENSPDLLAAR
310 320 330 340 350 360
KVAAHIGSEH HEVIFNSEEG IQAVEEVIFS LETYDITTVR ASIGMYLVSK YIRKKTDSVV
370 380 390 400 410 420
IFSGEGSDEL TQGYIYFHKA PSPEEAAEES ERLLKELYLF DVLRADRTTA AHGLELRVPF
430 440 450 460 470 480
LDHRFTSYYL SLPAELRIPK NGIEKYLLRQ SFEDSNLLPK EILWRPKEAF SDGIASVKKS
490 500 510 520 530 540
WFSILQDYID QQVDDLLLEK AAEKYPFNPP RTKESYYYRQ IFEKHYPGRS SWLPHYWMPR
550 560
WVEATDPSAR TLKHYKSAIQ E