Q5ZJU2

PR
Gene name
KLHL15 (RCJMB04_15l4)
Protein name
Kelch-like protein 15
Names
Species
Gallus gallus (Chicken)
KEGG Pathway
gga:418598
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

232-304 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5ZJU2

Entry ID Method Resolution Chain Position Source
AF-Q5ZJU2-F1 Predicted AlphaFoldDB

No variants for Q5ZJU2

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5ZJU2

No associated diseases with Q5ZJU2

6 regional properties for Q5ZJU2

Type Name Position InterPro Accession
domain BTB/POZ domain 23 - 128 IPR000210
repeat Kelch repeat type 1 328 - 426 IPR006652-1
repeat Kelch repeat type 1 427 - 488 IPR006652-2
domain BTB/Kelch-associated 133 - 237 IPR011705
domain Kelch-like protein 15, BTB/POZ domain 1 - 137 IPR030597
domain Kelch-like protein 15, BACK domain 128 - 235 IPR047030

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
Cul3-RING ubiquitin ligase complex A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

1 GO annotations of molecular function

Name Definition
ubiquitin ligase-substrate adaptor activity The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins.

3 GO annotations of biological process

Name Definition
negative regulation of double-strand break repair via homologous recombination Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination.
nuclear protein quality control by the ubiquitin-proteasome system The chemical reactions and pathways resulting in the breakdown of misfolded proteins via a mechanism in which the proteins are transported to the nucleus for ubiquitination, and then targeted to proteasomes for degradation.
protein ubiquitination The process in which one or more ubiquitin groups are added to a protein.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q96M94 KLHL15 Kelch-like protein 15 Homo sapiens (Human) PR
10 20 30 40 50 60
MAGDVEGFSS SIHDTSVSAG FRALYEEGLL LDVTLVIEDH QFQAHKALLA TQSDYFRIMF
70 80 90 100 110 120
TADMRERDQD KIHLKGLTAT GFSHVLQFMY YGTIELSMNT VHEILQAAMY VQLIEVVKFC
130 140 150 160 170 180
CSFLLAKICL ENCAEIMRLL DDFSVNIEGV REKLDSFLLE NFVPLMSRPD FLSYLSFEKL
190 200 210 220 230 240
MSYLDNDHLS RFPEIELYEA VQAWLRHDRR RWRHTDTIIQ NIRFCLMTPS SVFEKVKTSE
250 260 270 280 290 300
FYRYSRQLRH EVDQAMNYFH SVHQQPLMEM KSNKIRSAKP QTAVFRGMIG HSMVNSKILL
310 320 330 340 350 360
LHKPRVWWEL EGPQVPLRPD CLAIVNNFVF LLGGEELGPD GEFHASSKVF RYDPRQNTWL
370 380 390 400 410 420
RMADMSVPRS EFAVGVIGRY VYAVAGRTRD ETFYSTERYD ITEDKWEFVD PYPVNKYGHE
430 440 450 460 470 480
GTVLGNKLYI TGGITSSSTS KQVCVFDPSK EGTVEQRTRR TQVATNCWEN KCKMNYARCF
HKMISYNA