Q5ZIW5
Gene name |
VAC14 (RCJMB04_23c3) |
Protein name |
Protein VAC14 homolog |
Names |
|
Species |
Gallus gallus (Chicken) |
KEGG Pathway |
gga:415678 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5ZIW5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5ZIW5-F1 | Predicted | AlphaFoldDB |
No variants for Q5ZIW5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5ZIW5 | |||||
No associated diseases with Q5ZIW5
No regional properties for Q5ZIW5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for Q5ZIW5 | |||
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endosome membrane | The lipid bilayer surrounding an endosome. |
| extrinsic component of vacuolar membrane | The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region. |
| PAS complex | A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| phosphatidylinositol biosynthetic process | The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. |
| positive regulation of kinase activity | Any process that activates or increases the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNAERDLAPL | APSVVRALND | KLYEKRKVAA | LEIEKLVREF | VAQNNTSQVK | HVILILSQEF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ALSQHPHSRK | GGLIGLAACS | IALGKDSGLY | LKELIEPVLT | CFNDADSRLR | YYACEALYNI |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VKVARGSVLP | HFNVLFDGLS | KLAADPDPNV | KSGSELLDRL | LKDIVTESNQ | FDLVGFIPLL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RERIYSNNQY | ARQFIISWIL | VLESVPDINL | LDYLPEILDG | LFQILGDNSK | EIRKMCEVAL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| GEFLKEIKKN | PSSVKFAEMA | NILVIHCQAA | DDLIQLTAMC | WMREFIQLAG | RVMLPYSSGI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LTAVLPCLSY | DDRKKNIKEV | ANVCNQSLMK | LVIPEDDEMD | EAKQSITLSA | EPNPEEPVSK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| PEAASTGSLD | VSGDSSVSNA | SVCTVTSSER | IQVTLNLDGI | VQVLDCHLHD | TSIGMMTRIA |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VLKWLYHLYI | KTPRKMFRHT | DSLFPILLRT | LSDESDEVIL | KDLEVLAEIA | SSPAGQTEGY |
| 490 | 500 | 510 | 520 | 530 | 540 |
| GPSEAAEPRP | GQVELHVPIR | NSQLSSSGPK | GLECSPSTPT | MNSYFYKFMI | NLLKRFSSER |
| 550 | 560 | 570 | 580 | 590 | 600 |
| KLLETRGAFI | IRQLCLLLNT | ENIFHSMADI | LLREEDLKFA | STMVHTLNTI | LLTSSELFQL |
| 610 | 620 | 630 | 640 | 650 | 660 |
| RNQLKDLRTP | ESRNLFCCLY | RSWCHNPVTT | VSLCFLTQNY | KHAYDLIQKF | GDLEVTVDFL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TEVDKLVQLI | ECPIFTYLRL | QLLDVKNNPY | LIKALYGLLM | LLPQSSAFQL | LSHRLQCVPN |
| 730 | 740 | 750 | 760 | 770 | |
| PELMQSADGS | RASASSRRPA | SSTIDYTELL | QHFDKVQSKH | LEVRHQRAGR | AEQPERRVVL |