Q5Z2C8

PR
Gene name
purQ
Protein name
Phosphoribosylformylglycinamidine synthase subunit PurQ
Names
FGAM synthase, Formylglycinamide ribonucleotide amidotransferase subunit I, FGAR amidotransferase I, FGAR-AT I, Glutaminase PurQ, Phosphoribosylformylglycinamidine synthase subunit I
Species
Nocardia farcinica (strain IFM 10152)
KEGG Pathway
nfa:NFA_5680
EC number
3.5.1.2: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

165-225 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5Z2C8

Entry ID Method Resolution Chain Position Source
AF-Q5Z2C8-F1 Predicted AlphaFoldDB

No variants for Q5Z2C8

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5Z2C8

No associated diseases with Q5Z2C8

No regional properties for Q5Z2C8

Type Name Position InterPro Accession
No domain, repeats, and functional sites for Q5Z2C8

Functions

Description
EC Number 3.5.1.2 In linear amides
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
glutaminase activity Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3.
phosphoribosylformylglycinamidine synthase activity Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate.

2 GO annotations of biological process

Name Definition
'de novo' IMP biosynthetic process The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate.
glutamine metabolic process The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSARIGVITF PGTLDDVDAV RAVRLAGAEA VNLWHADADL KQVDAVIVPG GFSYGDYLRA
70 80 90 100 110 120
GAIARFAPVM GEVVRAAEQG MPVLGICNGF QVLCEAGLLP GALTRNEGLH FICRDQWLTV
130 140 150 160 170 180
ESVSTAWTSR YEPGAQILIP LKSGEGRYQA APAVLDELEG EGRVVFRYSG DNPNGSQRGI
190 200 210 220
AGISSANGRV VGLMPHPEHA TEALTGPSDD GLGLFLSVLD TLVTA