Q5Z048

PR
Gene name
valS
Protein name
Valine--tRNA ligase
Names
Valyl-tRNA synthetase, ValRS
Species
Nocardia farcinica (strain IFM 10152)
KEGG Pathway
nfa:NFA_13480
EC number
6.1.1.9: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5Z048

Entry ID Method Resolution Chain Position Source
AF-Q5Z048-F1 Predicted AlphaFoldDB

No variants for Q5Z048

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5Z048

No associated diseases with Q5Z048

6 regional properties for Q5Z048

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 57 - 68 IPR001412
domain Aminoacyl-tRNA synthetase, class Ia 29 - 439 IPR002300-1
domain Aminoacyl-tRNA synthetase, class Ia 450 - 583 IPR002300-2
domain Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase, anticodon-binding 626 - 770 IPR013155
domain Valyl-tRNA synthetase, tRNA-binding arm 826 - 891 IPR019499
domain Valyl tRNA synthetase, anticodon-binding domain 591 - 716 IPR033705

Functions

Description
EC Number 6.1.1.9 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
valine-tRNA ligase activity Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
valyl-tRNA aminoacylation The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSTAPDNSR NRADALPKSW DPSAVEAEMY ERWVSAGYFT ADPASGKPAY SIVLPPPNVT
70 80 90 100 110 120
GTLHMGHALD HTLMDTLARR KRMQGYEVLW LPGMDHAGIA TQTVVEKQLA VDGKTKEDFG
130 140 150 160 170 180
RELFVEKVWD WKRESGGAIQ WQMRALGDGV DWSRDRFTMD EGLSRAVQTM FKRLYDAGLI
190 200 210 220 230 240
YRAERLVNWS PELRTAISDI EVKHEDVEGE LVSLRYGSLN DDEPHVVVAT TRVETMLGDT
250 260 270 280 290 300
AVAVHPDDPR YRDLIGTTLE HPITGRQIPI VADDYVDPEF GSGAVKITPA HDPNDFEIGL
310 320 330 340 350 360
RHNLPMPTIM DERGRIANTG TEFDGMDRFE ARVKVRERLA REGRVVAEKR PYIHSVGHSE
370 380 390 400 410 420
RTGEPIEPRL SMQWWVKVEA LAKAAGDAVR NGQVVIHPAS QEPRWFEWVD NMHDWTISRQ
430 440 450 460 470 480
LWWGHRIPIW YGPDGEVVCL GPGETPPEGW VQDPDVLDTW FSSGLWPFST MGWPDATPEL
490 500 510 520 530 540
TKFYPTSVLV TGYDILFFWV ARMMMFGMYV AEDPALTAGK DPGQVQVPFK DIFLHGLIRD
550 560 570 580 590 600
QHGKKMSKSR GNGIDPLDWI RSYGADALRF TLARGAQPGG DLSVGEPHAL ASRSFVTKLF
610 620 630 640 650 660
NATKFALLNG AAPGELPDRG SLTDADRWIL DRLDEVLAEV DAAFDAYEFG KACEALYHFA
670 680 690 700 710 720
WDELCDWYLE LAKVQFAADG ARAESTRTVL GTVLDAVLRL LHPVIPFVTE SLWKALTGGE
730 740 750 760 770 780
SVVVAAWPTA SGVTPDADAA RRIADAQRLI TEIRRFRSDQ GLADKQKVSA KLIGVDSAEL
790 800 810 820 830 840
DALAPAIAAL ARLTEAGPDF AATASVEVRL SGATVTVELD TSGSVDLEAE RKRLEKDLAA
850 860 870 880 890
AQKELATTEG KLGNEAFLAK APEQVVDKIR TRRDVAAAEV ARIGARLAEL GAR