Q5YYP5

PR
Gene name
hisA
Protein name
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
Names
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Species
Nocardia farcinica (strain IFM 10152)
KEGG Pathway
nfa:NFA_18500
EC number
5.3.1.16: Interconverting aldoses and ketoses
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

154-227 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5YYP5

Entry ID Method Resolution Chain Position Source
AF-Q5YYP5-F1 Predicted AlphaFoldDB

No variants for Q5YYP5

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5YYP5

No associated diseases with Q5YYP5

1 regional properties for Q5YYP5

Type Name Position InterPro Accession
domain Band 7 domain 86 - 261 IPR001107

Functions

Description
EC Number 5.3.1.16 Interconverting aldoses and ketoses
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

2 GO annotations of molecular function

Name Definition
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.
phosphoribosylanthranilate isomerase activity Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

2 GO annotations of biological process

Name Definition
histidine biosynthetic process The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid.
tryptophan biosynthetic process The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSLVLLPAVD VANGEAVRLV QGEAGSETSY GSPRDAALAW QEAGAEWVHL VDLDAAFGRG
70 80 90 100 110 120
SNRELLAKVV GELDVKVELS GGIRDDDSLE AALATGCARV NLGTAALEDP QWCARAIAKH
130 140 150 160 170 180
GERIAVGLDV RIIDGDYRLR GRGWVSDGGD LWEVLERLER DGCSRYVVTD VTKDGTLTGP
190 200 210 220 230 240
NLELLSEVCA ATEAPVIASG GVSAIEDLVA IAGLVPEGVE GAIVGKALYA GRFTLPEALA
AVR