Q5YYA4

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Nocardia farcinica (strain IFM 10152)
KEGG Pathway
nfa:NFA_19910
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

255-423 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5YYA4

Entry ID Method Resolution Chain Position Source
AF-Q5YYA4-F1 Predicted AlphaFoldDB

No variants for Q5YYA4

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5YYA4

No associated diseases with Q5YYA4

2 regional properties for Q5YYA4

Type Name Position InterPro Accession
conserved_site Amino acid permease, conserved site 149 - 180 IPR004840
domain Amino acid permease/ SLC12A domain 124 - 589 IPR004841

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
RNA binding Binding to an RNA molecule or a portion thereof.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSGDIIDELT WRGLIAQSTD LDALRAALAA GPLTLYAGFD PTAASLHAGH LVPLLALKRF
70 80 90 100 110 120
QRAGHRPIVL AGGATGLIGD PRDVGERTMN SSDTVAEWAR RIRSQLERFV DLDDSPTGAV
130 140 150 160 170 180
IVNNMDWTGP LSAVDFLRDI GKHFSVNVML ARDTVKRRLE GDGMSYTEFS YMLLQANDYV
190 200 210 220 230 240
QLRRSFGCRL QVGGSDQWGN IIAGVELNRR LDGESVHALT VPLVTSADGK KFGKSTGGGS
250 260 270 280 290 300
LWLDPEMTSP YAWYQYFVNT ADADVVRYLR WFTFLDREEL AELERATAER PHAREAQRRL
310 320 330 340 350 360
AAEMTTLVHG EQHTRAVQLA SQALFGRGDL RELDEATLGA ALREAAGEGE VARVTPGEPA
370 380 390 400 410 420
TIVDLLVATG LAESRGAARR TVNEGGAAVN NQKIADPDWT PADGDYLHGR WLVVRRGKRN
MAGVLRDGN