Q5XWD5
Gene name |
CBLIF (GIF) |
Protein name |
Cobalamin binding intrinsic factor |
Names |
Gastric intrinsic factor, Intrinsic factor, IF, INF, Pancreatic intrinsic factor |
Species |
Canis lupus familiaris (Dog) (Canis familiaris) |
KEGG Pathway |
cfa:449477 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5XWD5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5XWD5-F1 | Predicted | AlphaFoldDB |
6 variants for Q5XWD5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs22919671 | 14 | A>V | No | EVA | |
| rs22906917 | 82 | S>G | No | EVA | |
| rs853013132 | 89 | V>I | No | EVA | |
| rs850963068 | 305 | V>I | No | EVA | |
| rs852365306 | 352 | R>C | No | EVA | |
| rs22954018 | 405 | R>H | No | EVA |
No associated diseases with Q5XWD5
3 regional properties for Q5XWD5
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Calreticulin/calnexin, conserved site | 101 - 116 | IPR018124-1 |
| conserved_site | Calreticulin/calnexin, conserved site | 133 - 141 | IPR018124-2 |
| conserved_site | Calreticulin/calnexin, conserved site | 246 - 258 | IPR018124-3 |
4 GO annotations of cellular component
| Name | Definition |
|---|---|
| apical plasma membrane | The region of the plasma membrane located at the apical end of the cell. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| extracellular space | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. |
| microvillus | Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| cobalamin binding | Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| cobalamin transport | The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| cobalt ion transport | The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| P27352 | CBLIF | Cobalamin binding intrinsic factor | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MAWFSLHLLH | LLWAAAGTST | WARSSCSVPQ | AAQHLVDGLQ | VLLEDSVSSA | APPNPSVLIA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| MNLAGALSAE | ARELLADRLG | ASDSAGLSVG | QLALTIMALN | SSCRDPGNKV | SVLYGQMEAW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PPSSPSAPAW | TFYGPSLAVL | ALCQEHPGRA | LPVAARLAKI | LAAGLSPFNT | DTGAMVTLAL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TCMYNKIPEG | SEEGYRTLFS | QVLKDVVENI | SMRIKDNGII | GDVYSTGLAM | QALSVTPEPP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| NKEWDCKKTM | DTILKEIEQG | KFHNPMSIAQ | ILPSLKGKTY | LDVPYVSCSP | GHQVQPTLPS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| QPSPVPTSAS | NITVAYTINN | QLKGVELVFN | ETIDVSVKDG | SVLLVVLEEA | QRRNPMFKFV |
| 370 | 380 | 390 | 400 | 410 | |
| TTMTSWGLVV | SSINNIAESV | HDRTYWQFLS | GKTPLNEGVA | DYTPRDHEHI | TANFTQY |