Q5XJS5
Gene name |
thoc6 (wdr58, zgc:101618) |
Protein name |
THO complex subunit 6 homolog |
Names |
WD repeat-containing protein 58 |
Species |
Danio rerio (Zebrafish) (Brachydanio rerio) |
KEGG Pathway |
dre:100004014 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5XJS5
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5XJS5-F1 | Predicted | AlphaFoldDB |
No variants for Q5XJS5
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5XJS5 | |||||
No associated diseases with Q5XJS5
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| nuclear speck | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. |
| THO complex | The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits. |
| transcription export complex | The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans. |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| RNA binding | Binding to an RNA molecule or a portion thereof. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| apoptotic process | A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. |
| mRNA export from nucleus | The directed movement of mRNA from the nucleus to the cytoplasm. |
| mRNA processing | Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide. |
| RNA splicing | The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MGPVELLHMS | VFSQSFSPCG | RYLAAGNNYG | EIAVFSLSAA | LSPDASERSQ | KPILNFTAHD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GPVFSLLSTE | SHLLSAGNGE | ISAWSWAELI | KKSTKAAWTR | KPNYETSLEI | PEINAMIINP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| KDNNLIVGGG | DNNIHIMDME | TGTFKSVLKG | HTDYIHCLSF | KEREGEILSG | GEDGAVRIWD |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SRTNRPVHCI | EVFKYEECAR | PQFGKWISCL | ATDSDWMLCG | GGPSLSLWHL | RSMSPTSVFP |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LSGCQREAVS | YQDLIMSVGE | GPYVSHCLHG | GTVKAQIPCS | PSSLNTLALN | LKNTEHRVMT |
| 310 | 320 | ||||
| VGGSSHQIDV | FTNFSYRALS | LSF |