Q5XH39
Gene name |
marchf8 (march8) |
Protein name |
E3 ubiquitin-protein ligase MARCHF8 |
Names |
Membrane-associated RING finger protein 8, Membrane-associated RING-CH protein VIII, MARCH-VIII, RING-type E3 ubiquitin transferase MARCHF8 |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:495072 |
EC number |
2.3.2.27: Aminoacyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5XH39
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5XH39-F1 | Predicted | AlphaFoldDB |
No variants for Q5XH39
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5XH39 | |||||
No associated diseases with Q5XH39
Functions
| Description | ||
|---|---|---|
| EC Number | 2.3.2.27 | Aminoacyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
5 GO annotations of cellular component
| Name | Definition |
|---|---|
| early endosome membrane | The lipid bilayer surrounding an early endosome. |
| endosome | A vacuole to which materials ingested by endocytosis are delivered. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| lysosomal membrane | The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm. |
| lysosome | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| ubiquitin-protein transferase activity | Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages. |
| zinc ion binding | Binding to a zinc ion (Zn). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| immune system process | Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MHSCWNMKLQ | NEKTLGHSVS | RSSNISKAGS | PTSVSAPSRF | PRTSVTPSSQ | DICRICHCEG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDESPLITPC | HCTGSLHFVH | QACLQQWIKS | SDTRCCELCK | FEFIMETKLK | PLRKWEKLQM |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TASERRKIMC | SVTFHVIAIT | CVVWSLYVLI | DRTAEEIRMG | QNNGILEWPF | WTKLVVVAIG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| FTGGLLFMYV | QCKVYVQLWK | RLKAYNRVIY | VQNCPETCKK | KIFEKSVIIE | PNLESKEALG |
| 250 | 260 | ||||
| IHHSDTNSSY | YTEPEDCGAA | ILQV |