Q5XE99
Gene name |
tyrS |
Protein name |
Tyrosine--tRNA ligase |
Names |
Tyrosyl-tRNA synthetase, TyrRS |
Species |
Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394) |
KEGG Pathway |
spa:M6_Spy0129 |
EC number |
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5XE99
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5XE99-F1 | Predicted | AlphaFoldDB |
No variants for Q5XE99
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5XE99 | |||||
1 associated diseases with Q5XE99
[MIM: 125630]: Vibratory urticaria (VBU)
An autosomal dominant disorder characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum. {ECO:0000269|PubMed:26841242}. Note=The disease is caused by variants affecting the gene represented in this entry.
Without disease ID
- An autosomal dominant disorder characterized by localized hives and systemic manifestations in response to dermal vibration, with coincident degranulation of mast cells and increased histamine levels in serum. {ECO:0000269|PubMed:26841242}. Note=The disease is caused by variants affecting the gene represented in this entry.
18 regional properties for Q5XE99
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| ptm | EGF-type aspartate/asparagine hydroxylation site | 85 - 96 | IPR000152-1 |
| ptm | EGF-type aspartate/asparagine hydroxylation site | 136 - 147 | IPR000152-2 |
| ptm | EGF-type aspartate/asparagine hydroxylation site | 180 - 191 | IPR000152-3 |
| ptm | EGF-type aspartate/asparagine hydroxylation site | 229 - 240 | IPR000152-4 |
| domain | GPS motif | 478 - 529 | IPR000203 |
| domain | EGF-like domain | 28 - 66 | IPR000742-1 |
| domain | EGF-like domain | 67 - 118 | IPR000742-2 |
| domain | EGF-like domain | 119 - 162 | IPR000742-3 |
| domain | EGF-like domain | 163 - 211 | IPR000742-4 |
| domain | EGF-like domain | 212 - 260 | IPR000742-5 |
| domain | EGF-like calcium-binding domain | 67 - 118 | IPR001881-1 |
| domain | EGF-like calcium-binding domain | 119 - 162 | IPR001881-2 |
| domain | EGF-like calcium-binding domain | 163 - 211 | IPR001881-3 |
| domain | EGF-like calcium-binding domain | 212 - 260 | IPR001881-4 |
| domain | GPCR, family 2-like, transmembrane domain | 536 - 782 | IPR017981 |
| conserved_site | GPCR, family 2, secretin-like, conserved site | 770 - 785 | IPR017983 |
| conserved_site | EGF-like calcium-binding, conserved site | 119 - 145 | IPR018097-1 |
| conserved_site | EGF-like calcium-binding, conserved site | 212 - 238 | IPR018097-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 6.1.1.1 | Ligases forming aminoacyl-tRNA and related compounds |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| RNA binding | Binding to an RNA molecule or a portion thereof. |
| tyrosine-tRNA ligase activity | Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+). |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| tyrosyl-tRNA aminoacylation | The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MNIFEELKAR | GLVFQTTDEQ | ALVKALTEGQ | VSYYTGYDPT | ADSLHLGHLV | AILTSRRLQL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AGHKPYALVG | GATGLIGDPS | FKDAERSLQT | KETVLEWSDK | IKGQLSAFLD | FENGDNKAEL |
| 130 | 140 | 150 | 160 | 170 | 180 |
| VNNYDWFSQI | SFIDFLRDVG | KYFTVNYMMS | KDSVKKRIET | GISYTEFAYQ | IMQGYDFYEL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| NDKHNVTLQI | GGSDQWGNMT | AGTELLRKKA | DKTGHVMTVP | LITDSTGKKF | GKSEGNAVWL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| DADKTSPYEM | YQFWLNVMDD | DAVRFLKIFT | FLSLDEIAEI | ETQFNAARHE | RLAQKTLARE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VVTLVHGEEA | YKQALNITEQ | LFAGNIKNLS | ANELKQGLSN | VPNYHVQSED | SLNLVDMLVT |
| 370 | 380 | 390 | 400 | 410 | |
| AGISPSKRQA | REDVQNGAIY | INGDRVQDLD | YQLSNDDKID | DQLTVIRRGK | KKYAVLTY |