Q5X7H7

PR
Gene name
tyrS
Protein name
Tyrosine--tRNA ligase
Names
Tyrosyl-tRNA synthetase, TyrRS
Species
Legionella pneumophila (strain Paris)
KEGG Pathway
lpp:lpp0628
EC number
6.1.1.1: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

55-124 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5X7H7

Entry ID Method Resolution Chain Position Source
AF-Q5X7H7-F1 Predicted AlphaFoldDB

No variants for Q5X7H7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5X7H7

No associated diseases with Q5X7H7

2 regional properties for Q5X7H7

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 42 - 52 IPR001412
domain RNA-binding S4 domain 336 - 398 IPR002942

Functions

Description
EC Number 6.1.1.1 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
RNA binding Binding to an RNA molecule or a portion thereof.
tyrosine-tRNA ligase activity Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+).

1 GO annotations of biological process

Name Definition
tyrosyl-tRNA aminoacylation The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIVQDSVCSE LMRGCEEILP VPELEKKLQK GIPLKIKAGF DPTAPDLHLG HTVLLNKLRQ
70 80 90 100 110 120
FQQFGHEVIF LIGDFTAMIG DPTGKNVTRM PLSQETVLEN AKTYQHQVFK ILDPDKTTVA
130 140 150 160 170 180
FNSQWLNKFN AVDLIRLAAT HTVARMLERD DFNKRYTTGQ PIAIHEFLYP LLQGYDSVAL
190 200 210 220 230 240
KADVELGGTD QKFNLLMGRE LQKHYGFEPQ VVMMTPLIEG LDGVKKMSKS LDNYIGINET
250 260 270 280 290 300
PEQIFGKIMS VSDELMWRYI DLLSFKTGKE IQQLKQSVLE GKNPRDVKID FAKEIVARFH
310 320 330 340 350 360
DQTQAELAHN NFIERFQKGN IPEDLEELSL VIVEPIALAQ LLKQIDLTAS TSESIRMVKQ
370 380 390 400
GAVKVDGDKI SDPSLKLPIG KSYIIQVGKR RIAKLSIQQA D