Q5X1C7

PR
Gene name
pnp
Protein name
Polyribonucleotide nucleotidyltransferase
Names
Polynucleotide phosphorylase, PNPase
Species
Legionella pneumophila (strain Paris)
KEGG Pathway
lpp:lpp2816
EC number
2.7.7.8: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

665-729 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5X1C7

Entry ID Method Resolution Chain Position Source
AF-Q5X1C7-F1 Predicted AlphaFoldDB

No variants for Q5X1C7

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5X1C7

No associated diseases with Q5X1C7

9 regional properties for Q5X1C7

Type Name Position InterPro Accession
domain Exoribonuclease, phosphorolytic domain 1 14 - 143 IPR001247-1
domain Exoribonuclease, phosphorolytic domain 1 323 - 455 IPR001247-2
domain S1 domain 618 - 689 IPR003029
domain K Homology domain 551 - 616 IPR004087
domain K Homology domain, type 1 555 - 612 IPR004088
domain Exoribonuclease, phosphorolytic domain 2 146 - 208 IPR015847-1
domain Exoribonuclease, phosphorolytic domain 2 458 - 528 IPR015847-2
domain Polyribonucleotide nucleotidyltransferase, RNA-binding domain 241 - 319 IPR015848
domain RNA-binding domain, S1 619 - 689 IPR022967

Functions

Description
EC Number 2.7.7.8 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
magnesium ion binding Binding to a magnesium (Mg) ion.
polyribonucleotide nucleotidyltransferase activity Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate.
RNA binding Binding to an RNA molecule or a portion thereof.

2 GO annotations of biological process

Name Definition
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
RNA processing Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAKITKEIVF GNHKLILETG EVARQADGAV MASMNGTQVL VTVVWKKDSG ESNDFFPLTV
70 80 90 100 110 120
NYQEKFYAIG KIPGGFNKRE GRPSDNETLI SRLIDRPIRP LFPDNFFNEV QIIATVLSLN
130 140 150 160 170 180
PEVSPDIIAM IGASAALSIS GVPFNGPIGA ARVGYKDGVY LLNPSRKEQE ESKLDLVIAG
190 200 210 220 230 240
TKDAILMVES EAQELSEDIM RGAMLYGHEM MKSVIKSIEE LAREVGKSKP EWKAPEIDTV
250 260 270 280 290 300
LKARINDVAR NEVEAAYLIK DKQQRYQRLD ELREQTISAL LAENDELNAD VIANMFGELE
310 320 330 340 350 360
RSIVRNRILD GEPRIDGRDH RTVRPISIRT KFLERTHGSC LFTRGETQAI VVATLGNERD
370 380 390 400 410 420
AQILDGISGE TRDRFMLHYN FPPYSVGETG QVGSPKRREI GHGRLAKRAL MAVLPDTNEF
430 440 450 460 470 480
PYVLRIVSEI TESNGSSSMA TVCGTSLALM DAGVPLKAPV AGVAMGLIKE GDRYAVLTDI
490 500 510 520 530 540
LGDEDHLGDM DFKVAGTEKG ITALQMDIKI SGITNEIMER ALEQALEGRT HILGVMNNAL
550 560 570 580 590 600
AEHRTELSQH APRITTMKVA EDKIRTIIGK GGATIKGLIE STGVSIDIDD SGVIQLFSPD
610 620 630 640 650 660
KMALEEAQKQ IKALIAEIEV GQTYQGKVSK IVDFGAFINL LPGKDGLLHI SQICAERTQK
670 680 690 700 710 720
VEEVLQEGQE IEVFVAGIDK QGRVKLEWKD KPQAEAKEVE GASVSATFLT MEEQSEEINS
GNKISEEEE