Q5X105

PR
Gene name
metG
Protein name
Methionine--tRNA ligase
Names
Methionyl-tRNA synthetase, MetRS
Species
Legionella pneumophila (strain Paris)
KEGG Pathway
lpp:lpp2941
EC number
6.1.1.10: Ligases forming aminoacyl-tRNA and related compounds
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

513-590 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5X105

Entry ID Method Resolution Chain Position Source
AF-Q5X105-F1 Predicted AlphaFoldDB

No variants for Q5X105

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5X105

No associated diseases with Q5X105

7 regional properties for Q5X105

Type Name Position InterPro Accession
conserved_site Aminoacyl-tRNA synthetase, class I, conserved site 14 - 25 IPR001412
domain tRNA-binding domain 570 - 670 IPR002547
domain Methionyl-tRNA synthetase, beta subunit, C-terminal 536 - 670 IPR004495
domain Methionyl/Leucyl tRNA synthetase 7 - 394 IPR015413
domain Methioninyl-tRNA synthetase core domain 6 - 362 IPR033911-1
domain Methioninyl-tRNA synthetase core domain 382 - 393 IPR033911-2
domain Methionyl-tRNA synthetase, anticodon-binding domain 376 - 514 IPR041872

Functions

Description
EC Number 6.1.1.10 Ligases forming aminoacyl-tRNA and related compounds
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

4 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
metal ion binding Binding to a metal ion.
methionine-tRNA ligase activity Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met).
tRNA binding Binding to a transfer RNA.

1 GO annotations of biological process

Name Definition
methionyl-tRNA aminoacylation The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTSERKMLVT SALPYANGHL HLGHLVEHIQ TDIWVRTHKM LGIQCISVCG DDAHGTPIML
70 80 90 100 110 120
KAEQLGITPE ALTAEIKLSH EKDFKAFAID YDYYHTTHSP ENQVLATTIF ERLQAGGDIV
130 140 150 160 170 180
KKTIRQFYDP VKQMFLPDRY VKGTCPKCAA VDQYGDNCEV CGATYSPTDL INPVSVISGA
190 200 210 220 230 240
SPVEKESEHY FFDLPLYEEL LKDWTRKGHL QAEVTNKLSE WFEAGLKQWD ISRDAPYFGF
250 260 270 280 290 300
PIPGVPDKYF YVWLDAPIGY MASFKKYCDE RGVSFDEFWD KASKTELYHF VGKDIVYFHA
310 320 330 340 350 360
LFWPAMLAAS GFRTPTAVYT HGFLTVEGQK MSKSRGTFIE ARAYLAHLHP EYLRYYFAAK
370 380 390 400 410 420
LNGRVDDLDL NFDDFVNRVN ADLVGKVVNI ASRCAGFINK RFDNRLSSEL NDPKLHNDLL
430 440 450 460 470 480
SARESVIDAF VSRDYARAIR QIMDCADKVN QYIDANKPWV LAKDESKLNE VHAICTMGIN
490 500 510 520 530 540
LFRILITYLK PVLPMMAKAS EEFLNSEPLH WGSIDKPLLN HRINTFKPLM VRVEKEKIEA
550 560 570 580 590 600
MLVQSKESLM TTPVKENTPV EDANLISIED FAKVDLRIAK IVNAEPVEGA DKLMRLILDL
610 620 630 640 650 660
GDAQKQVFAG IKKAYDAEEL IGRLTVMVAN LEPRTMRFGV SEGMVLAAGD GQGIYLLQPD
AGALPGMKVK