Q5WX75

PR
Gene name
hemF
Protein name
Oxygen-dependent coproporphyrinogen-III oxidase
Names
CPO, Coprogen oxidase, Coproporphyrinogenase
Species
Legionella pneumophila (strain Lens)
KEGG Pathway
lpf:lpl1223
EC number
1.3.3.3: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-78 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for Q5WX75

Entry ID Method Resolution Chain Position Source
AF-Q5WX75-F1 Predicted AlphaFoldDB

No variants for Q5WX75

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for Q5WX75

No associated diseases with Q5WX75

4 regional properties for Q5WX75

Type Name Position InterPro Accession
domain Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase 162 - 276 IPR006151
domain Glutamyl-tRNA reductase, N-terminal 33 - 139 IPR015895
domain Tetrapyrrole biosynthesis, glutamyl-tRNA reductase, dimerisation domain 294 - 381 IPR015896
conserved_site Glutamyl-tRNA reductase, conserved site 82 - 105 IPR018214

Functions

Description
EC Number 1.3.3.3 With oxygen as acceptor
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
coproporphyrinogen oxidase activity Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX.
metal ion binding Binding to a metal ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.

1 GO annotations of biological process

Name Definition
protoporphyrinogen IX biosynthetic process The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPISKTLPYN AIEQIKSYLL QLQNTICVSL ESIDGQTKFH EDSWQRAAGG GGKTRIMANG
70 80 90 100 110 120
NVFEKAGVNF SHVSGEQLPA SASAHREELA GRHFSALGVS LVIHPQNPYV PTTHANVRFF
130 140 150 160 170 180
VAEKEDSEPV WWFGGGFDLT PYYGFIEDCE HWHQTALNAC LPFGETIYPK FKRWCDDYFF
190 200 210 220 230 240
IKHRNEARGI GGLFFDDYNE ISFDHSFELM RSIGDHFILA YEPIVARRKD IPFGNREKAF
250 260 270 280 290 300
QNYRRGRYAE FNLVYDRGTL FGLQSGGRTE SILMSLPPIV HWEYNWHPEK GSNEEKLYTD
FLPAKDWLK