Q5WX50
Gene name |
hmgA |
Protein name |
Homogentisate 1,2-dioxygenase |
Names |
HGDO, Homogentisate oxygenase, Homogentisic acid oxidase, Homogentisicase |
Species |
Legionella pneumophila (strain Lens) |
KEGG Pathway |
lpf:lpl1248 |
EC number |
1.13.11.5: With incorporation of two atoms of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for Q5WX50
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-Q5WX50-F1 | Predicted | AlphaFoldDB |
No variants for Q5WX50
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for Q5WX50 | |||||
No associated diseases with Q5WX50
5 regional properties for Q5WX50
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | S-adenosylmethionine synthetase, N-terminal | 3 - 100 | IPR022628 |
| domain | S-adenosylmethionine synthetase, central domain | 113 - 229 | IPR022629 |
| domain | S-adenosylmethionine synthetase, C-terminal | 231 - 368 | IPR022630 |
| conserved_site | S-adenosylmethionine synthetase, conserved site | 114 - 124 | IPR022631-1 |
| conserved_site | S-adenosylmethionine synthetase, conserved site | 257 - 265 | IPR022631-2 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.13.11.5 | With incorporation of two atoms of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| homogentisate 1,2-dioxygenase activity | Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+). |
| iron ion binding | Binding to an iron (Fe) ion. |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| L-phenylalanine catabolic process | The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid. |
| tyrosine catabolic process | The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MYLQGFGNYH | HSEAVKGALP | PNQNSPQHCS | LGLYAEQLSG | TSFTRPRHNN | LRSWLYRILP |
| 70 | 80 | 90 | 100 | 110 | 120 |
| TVTQGTYYPY | EFNIMQPLVD | ELSPNAMRWS | PLYNSSQIKC | DFVEGLFHIA | GSPLVNAYTY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YCNHSMSDKY | FANNDGELLF | VPYTGEIHLH | TEFGKLMLSS | GSIAVIPRGV | KFKVEVISKE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| AKGYLCENSG | NPLTLPQLGP | IGANGLANPR | HFQYPVAAFE | NSVGEHTIIC | KNQKKLWFTV |
| 250 | 260 | 270 | 280 | 290 | 300 |
| CNHSPLNVVA | WHGNYAPYCY | DLSLFNTINT | VSFDHPDPSI | FTVLTSESEI | PGVSNLDFVI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| FPPRWMVAEH | TFRPPYFHRN | YMNELMGLVY | GEYDAKKEGF | IPGGISIHNC | MTPHGPDYES |
| 370 | 380 | 390 | 400 | 410 | |
| YEIAASQDLK | PNYINSLAFM | FETKDYWQVT | EQAYRHPSRQ | IDYLNCWQGF | KIEFSQ |